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Information Profiles on Potential Occupational Hazards: Phthalates.


PB89215818

Publication Date 1982
Page Count 151
Abstract Information profiles are presented for these phthalates: butyl-benzyl-phthalate (85687), diallyl-phthalate (131179), di-n-butyl-phthalate (84742), di-2-ethylhexyl-phthalate (117817), diethyl-phthalate (84662), diisodecyl-phthalate (26761400), diisononyl-phthalate (28553120), dimethyl-phthalate (131113), ditridecyl-phthalate (119062), diundecyl-phthalate (3648202), N-dexy-N-decyl-phthalate (25724587) and mixed dialkyl (C7 to C11) phthalates. In general the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Ingestion of di-n-butyl-phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinvyl-chloride bags that contained residual di-2-ethylhexyl-phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl-phthalate showed no adverse health effects.
Keywords
  • Industrial medicine
  • Phthalates
  • Exposure
  • Toxicity
  • Chemical analysis
  • Production
  • Utilization
  • Control equipment
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 85-68-7
  • CAS 131-17-9
  • CAS 84-74-2
  • CAS 117-81-7
  • CAS 84-66-2
  • CAS 26761-40-0
  • CAS 28533-12-0
  • CAS 131-11-3
  • CAS 119-06-2
  • CAS 3648-20-2
  • CAS 25724-58-7
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
Title Note Draft rept. (Second).
NTIS Issue Number 198921
Contract Number
  • PHS-NIOSH-210-79-0030
Information Profiles on Potential Occupational Hazards: Phthalates.
Information Profiles on Potential Occupational Hazards: Phthalates.
PB89215818

  • Industrial medicine
  • Phthalates
  • Exposure
  • Toxicity
  • Chemical analysis
  • Production
  • Utilization
  • Control equipment
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 85-68-7
  • CAS 131-17-9
  • CAS 84-74-2
  • CAS 117-81-7
  • CAS 84-66-2
  • CAS 26761-40-0
  • CAS 28533-12-0
  • CAS 131-11-3
  • CAS 119-06-2
  • CAS 3648-20-2
  • CAS 25724-58-7
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-79-0030
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