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Information Profiles on Potential Occupational Hazards: Phthalates.

PB89215818

Publication Date	1982
Page Count	151
Abstract	Information profiles are presented for these phthalates: butyl-benzyl-phthalate (85687), diallyl-phthalate (131179), di-n-butyl-phthalate (84742), di-2-ethylhexyl-phthalate (117817), diethyl-phthalate (84662), diisodecyl-phthalate (26761400), diisononyl-phthalate (28553120), dimethyl-phthalate (131113), ditridecyl-phthalate (119062), diundecyl-phthalate (3648202), N-dexy-N-decyl-phthalate (25724587) and mixed dialkyl (C7 to C11) phthalates. In general the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Ingestion of di-n-butyl-phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinvyl-chloride bags that contained residual di-2-ethylhexyl-phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl-phthalate showed no adverse health effects.
Keywords	Industrial medicine Phthalates Exposure Toxicity Chemical analysis Production Utilization Control equipment Occupational safety and health Toxic substances Biological effects CAS 85-68-7 CAS 131-17-9 CAS 84-74-2 CAS 117-81-7 CAS 84-66-2 CAS 26761-40-0 CAS 28533-12-0 CAS 131-11-3 CAS 119-06-2 CAS 3648-20-2 CAS 25724-58-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Draft rept. (Second).
NTIS Issue Number	198921
Contract Number	PHS-NIOSH-210-79-0030

Information Profiles on Potential Occupational Hazards: Phthalates.

Information Profiles on Potential Occupational Hazards: Phthalates.
PB89215818

Publication Date	1982
Page Count	151
Abstract	Information profiles are presented for these phthalates: butyl-benzyl-phthalate (85687), diallyl-phthalate (131179), di-n-butyl-phthalate (84742), di-2-ethylhexyl-phthalate (117817), diethyl-phthalate (84662), diisodecyl-phthalate (26761400), diisononyl-phthalate (28553120), dimethyl-phthalate (131113), ditridecyl-phthalate (119062), diundecyl-phthalate (3648202), N-dexy-N-decyl-phthalate (25724587) and mixed dialkyl (C7 to C11) phthalates. In general the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Ingestion of di-n-butyl-phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinvyl-chloride bags that contained residual di-2-ethylhexyl-phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl-phthalate showed no adverse health effects.
Keywords	Industrial medicine Phthalates Exposure Toxicity Chemical analysis Production Utilization Control equipment Occupational safety and health Toxic substances Biological effects CAS 85-68-7 CAS 131-17-9 CAS 84-74-2 CAS 117-81-7 CAS 84-66-2 CAS 26761-40-0 CAS 28533-12-0 CAS 131-11-3 CAS 119-06-2 CAS 3648-20-2 CAS 25724-58-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 41I - Job Environment 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
Title Note	Draft rept. (Second).
NTIS Issue Number	198921
Contract Number	PHS-NIOSH-210-79-0030