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Information Profiles on Potential Occupational Hazards: Thiourea and Compounds.


PB89215685

Publication Date 1982
Page Count 136
Abstract Information profiles are presented for thiourea and the following thiourea compounds: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'-bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2-thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N'N'-di-o-tolylthiourea (137973), 3-ethyl-1-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2-methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2-thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2-thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3-trimethyl-2-thiourea (2489772). Most of the compounds were highly toxic to rodents. Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications include headache, anxiety, fever, skin rash, and gastrointestinal disturbances.
Keywords
  • Industrial medicine
  • Thioureas
  • Toxicity
  • Exposure
  • Chemical analysis
  • Utilization
  • Production
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 103-85-5
  • CAS 105-81-7
  • CAS 109-57-9
  • CAS 3084-25-1
  • CAS 51872-26-5
  • CAS 86-88-4
  • CAS 32900-06-4
  • CAS 109-46-6
  • CAS 2986-17-6
  • CAS 534-13-14
  • CAS 137-97-3
  • CAS 2782-91-4
  • CAS 102-08-9
  • CAS 105-55-5
  • CAS 15361-86-1
  • CAS 625-53-6
  • CAS 1000-83-5
  • CAS 614-78-8
  • CAS 62-56-6
  • CAS 2489-77-2
  • CAS 96-45-7
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
Title Note Draft rept. (Second).
NTIS Issue Number 198921
Contract Number
  • PHS-NIOSH-210-79-0030
Information Profiles on Potential Occupational Hazards: Thiourea and Compounds.
Information Profiles on Potential Occupational Hazards: Thiourea and Compounds.
PB89215685

  • Industrial medicine
  • Thioureas
  • Toxicity
  • Exposure
  • Chemical analysis
  • Utilization
  • Production
  • Occupational safety and health
  • Toxic substances
  • Biological effects
  • CAS 103-85-5
  • CAS 105-81-7
  • CAS 109-57-9
  • CAS 3084-25-1
  • CAS 51872-26-5
  • CAS 86-88-4
  • CAS 32900-06-4
  • CAS 109-46-6
  • CAS 2986-17-6
  • CAS 534-13-14
  • CAS 137-97-3
  • CAS 2782-91-4
  • CAS 102-08-9
  • CAS 105-55-5
  • CAS 15361-86-1
  • CAS 625-53-6
  • CAS 1000-83-5
  • CAS 614-78-8
  • CAS 62-56-6
  • CAS 2489-77-2
  • CAS 96-45-7
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 41I - Job Environment
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-79-0030
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