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Occupational Risks of Pesticide Exposure for Females.

PB89200943

Publication Date	1988
Personal Author	Swartz, W. J.
Page Count	34
Abstract	The effects of a reproductive toxicant on the ovary and ovulatory ability of mice as well as on the embryological development of the ovaries of mice exposed before birth to the same toxic agent were investigated. Specific attention was given to the effect of these agents on steroid hormone levels, specific follicle populations and cell surface characteristics of the various cellular components making up the ovary. Virgin female CD-1-mice were exposed to 0.062, 0.125, or 0.25 milligrams (mg) chlordecone (143500), estradiol-17B (0.1mg), or sesame oil (control group) in a 0.2 milliliter (ml) volume by oral gavage. Significant decreases in the ovulatory response of the ovaries were noted after 4 to 6 weeks of exposure to chlordecone when compared to the other two study groups. A significant increase was noted in the livers of chlordecone exposed mice, increasing in a linear fashion from 2 to 6 weeks of exposure. During this time chlordecone was accumulated by the liver. No external malformations or deviations from the normal sex ratio were seen to result from chlordecone exposure. Vaginal openings were noted in the female offspring of treated mice at significantly earlier times than for those from nontreated animals. This was also true for female offspring of the second litter to be born after the exposure of the mother.
Keywords	Pesticides Reproductive system Females Toxicity Mice Genital diseases Animals Hazardous materials Bioassay Occupational safety and health Animal experiments CAS 143-50-0
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	Louisiana State Univ. Medical Center, New Orleans.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB84-241645. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 15 Sep 85-31 Aug 88.
NTIS Issue Number	198920

Occupational Risks of Pesticide Exposure for Females.

Occupational Risks of Pesticide Exposure for Females.
PB89200943

Publication Date	1988
Personal Author	Swartz, W. J.
Page Count	34
Abstract	The effects of a reproductive toxicant on the ovary and ovulatory ability of mice as well as on the embryological development of the ovaries of mice exposed before birth to the same toxic agent were investigated. Specific attention was given to the effect of these agents on steroid hormone levels, specific follicle populations and cell surface characteristics of the various cellular components making up the ovary. Virgin female CD-1-mice were exposed to 0.062, 0.125, or 0.25 milligrams (mg) chlordecone (143500), estradiol-17B (0.1mg), or sesame oil (control group) in a 0.2 milliliter (ml) volume by oral gavage. Significant decreases in the ovulatory response of the ovaries were noted after 4 to 6 weeks of exposure to chlordecone when compared to the other two study groups. A significant increase was noted in the livers of chlordecone exposed mice, increasing in a linear fashion from 2 to 6 weeks of exposure. During this time chlordecone was accumulated by the liver. No external malformations or deviations from the normal sex ratio were seen to result from chlordecone exposure. Vaginal openings were noted in the female offspring of treated mice at significantly earlier times than for those from nontreated animals. This was also true for female offspring of the second litter to be born after the exposure of the mother.
Keywords	Pesticides Reproductive system Females Toxicity Mice Genital diseases Animals Hazardous materials Bioassay Occupational safety and health Animal experiments CAS 143-50-0
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety
Corporate Authors	Louisiana State Univ. Medical Center, New Orleans.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB84-241645. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Rept. for 15 Sep 85-31 Aug 88.
NTIS Issue Number	198920