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Screening of Priority Chemicals for Reproductive Hazards. Benzethonium Chloride (Cas. No. 121-54-0); 3-Ethoxy-1-Propanol (Cas. No. 111-35-3); Acetone (Cas. No. 67-64-1).

PB89139083

Publication Date	1987
Page Count	62
Abstract	Benzethonium-chloride (121540), 3-ethoxy-1-propanol (111353), and acetone (67641) were screened for their ability to cause adverse reproductive effects as evidenced through the postnatal mouse screening test. Phases one and two were intended to identify the appropriate dose levels, while phase three was intended to determine reproductive effects. Treatment was administered to female CD-1-mice by gavage on 5 consecutive days during phase one and on gestation days six through 15 in phases two and three. Benzethonium-chloride caused excessive maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups but had no effect on litter size or weight gain. 3-Ethoxy-1-propanol caused a high maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups. No effect was observed on litter size or weight gain. Acetone did not cause an increase in maternal mortality but did increase the weight gain by the pups and decreased the reproductive index, the percent survival of the pups and the birth weight of the pups. No effect was noted on litter size.
Keywords	Propanols Acetone Reproduction(Biology) Toxicology Experimental design Solvents Organic solvents Tables(Data) Ketones Mice Exposure Laboratory animals Industrial hygiene Anilines Toxic substances Ethoxy propanol Benzethonium chloride Ammonium compounds Dose-response relationships Fetal death CAS 121-54-0 CAS 111-35-3 CAS 67-64-1 Maternal mortality Occupational safety and health Body weight
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB89-139075. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735

Screening of Priority Chemicals for Reproductive Hazards. Benzethonium Chloride (Cas. No. 121-54-0); 3-Ethoxy-1-Propanol (Cas. No. 111-35-3); Acetone (Cas. No. 67-64-1).

Screening of Priority Chemicals for Reproductive Hazards. Benzethonium Chloride (Cas. No. 121-54-0); 3-Ethoxy-1-Propanol (Cas. No. 111-35-3); Acetone (Cas. No. 67-64-1).
PB89139083

Publication Date	1987
Page Count	62
Abstract	Benzethonium-chloride (121540), 3-ethoxy-1-propanol (111353), and acetone (67641) were screened for their ability to cause adverse reproductive effects as evidenced through the postnatal mouse screening test. Phases one and two were intended to identify the appropriate dose levels, while phase three was intended to determine reproductive effects. Treatment was administered to female CD-1-mice by gavage on 5 consecutive days during phase one and on gestation days six through 15 in phases two and three. Benzethonium-chloride caused excessive maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups but had no effect on litter size or weight gain. 3-Ethoxy-1-propanol caused a high maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups. No effect was observed on litter size or weight gain. Acetone did not cause an increase in maternal mortality but did increase the weight gain by the pups and decreased the reproductive index, the percent survival of the pups and the birth weight of the pups. No effect was noted on litter size.
Keywords	Propanols Acetone Reproduction(Biology) Toxicology Experimental design Solvents Organic solvents Tables(Data) Ketones Mice Exposure Laboratory animals Industrial hygiene Anilines Toxic substances Ethoxy propanol Benzethonium chloride Ammonium compounds Dose-response relationships Fetal death CAS 121-54-0 CAS 111-35-3 CAS 67-64-1 Maternal mortality Occupational safety and health Body weight
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB89-139075. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735