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Screening of Priority Chemicals for Reproductive Hazards. Triorthocresyl Phosphate (Cas. No. 78-30-8); 4,4'-Thiobis (6-t-Butyl-m-Cresol (Cas. No. 96-69-5); 13-Cis Retinoic Acid (Cas. No. 4759-48-2).

PB89139075

Publication Date	1987
Page Count	68
Abstract	Triorthocresyl-phosphate (78308), 4,4'-thiobis(6-t-butyl-m-cresol) (96695), and 13-cis-retinoic-acid (4759482) were screened for their potential to cause adverse reproductive effects using a postnatal mouse screening test. Experiments were designed to determine the appropriate dose levels for the different compounds and the reproductive effects were studied. The predicted median lethal dose for triorthocresyl-phosphate was 515 mg/kg/day and for 4,4'-thiobis it was 485 mg/kg/day. The 13-cis-retinoic-acid (4759482) was administered at 85 mg/kg/day, due to the limited amount of chemical available. All animals received a constant volume of 10 milliliters/kilogram/day. Triorthocresyl-phosphate caused an increased maternal mortality and a decreased number of viable litters but had no effect on litter size or birth weight gain. 4,4'-Thiobis(6-t-butyl-m-cresol) caused increases in maternal mortality and a decreased percent of pup survival while not affecting the number of viable litters, the litter size, birth weight or weight gain of the pups. 13-cis-Retinoic-acid had no effect on maternal mortality, the number of viable litters, litter size, or pup birth weight.
Keywords	Reproduction(Biology) Toxicology Experimental design Tables(Data) Mice Laboratory animals Industrial hygiene Lethal dosage Exposure Triorthocresyl phosphate Tretinoin Cresols Toxic substances Screening Dose-response relationships CAS 78-30-8 CAS 96-69-5 CAS 4759-48-2 Teratogenesis Phosphates Occupational safety and health Body weight Fetal death Maternal mortality
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB8-89-139067 and PB86-197605. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735

Screening of Priority Chemicals for Reproductive Hazards. Triorthocresyl Phosphate (Cas. No. 78-30-8); 4,4'-Thiobis (6-t-Butyl-m-Cresol (Cas. No. 96-69-5); 13-Cis Retinoic Acid (Cas. No. 4759-48-2).

Screening of Priority Chemicals for Reproductive Hazards. Triorthocresyl Phosphate (Cas. No. 78-30-8); 4,4'-Thiobis (6-t-Butyl-m-Cresol (Cas. No. 96-69-5); 13-Cis Retinoic Acid (Cas. No. 4759-48-2).
PB89139075

Publication Date	1987
Page Count	68
Abstract	Triorthocresyl-phosphate (78308), 4,4'-thiobis(6-t-butyl-m-cresol) (96695), and 13-cis-retinoic-acid (4759482) were screened for their potential to cause adverse reproductive effects using a postnatal mouse screening test. Experiments were designed to determine the appropriate dose levels for the different compounds and the reproductive effects were studied. The predicted median lethal dose for triorthocresyl-phosphate was 515 mg/kg/day and for 4,4'-thiobis it was 485 mg/kg/day. The 13-cis-retinoic-acid (4759482) was administered at 85 mg/kg/day, due to the limited amount of chemical available. All animals received a constant volume of 10 milliliters/kilogram/day. Triorthocresyl-phosphate caused an increased maternal mortality and a decreased number of viable litters but had no effect on litter size or birth weight gain. 4,4'-Thiobis(6-t-butyl-m-cresol) caused increases in maternal mortality and a decreased percent of pup survival while not affecting the number of viable litters, the litter size, birth weight or weight gain of the pups. 13-cis-Retinoic-acid had no effect on maternal mortality, the number of viable litters, litter size, or pup birth weight.
Keywords	Reproduction(Biology) Toxicology Experimental design Tables(Data) Mice Laboratory animals Industrial hygiene Lethal dosage Exposure Triorthocresyl phosphate Tretinoin Cresols Toxic substances Screening Dose-response relationships CAS 78-30-8 CAS 96-69-5 CAS 4759-48-2 Teratogenesis Phosphates Occupational safety and health Body weight Fetal death Maternal mortality
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB8-89-139067 and PB86-197605. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735