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Screening of Priority Chemicals for Reproductive Hazards. Monoethanolamine (Cas. No. 141-43-5); Diethanolamine (Cas. No. 111-42-2); Triethanolamine (Cas. No. 102-71-6).

PB89139067

Publication Date	1987
Page Count	64
Abstract	Monoethanolamine (141435), diethanolamine (111422), and triethanolamine (102716) were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Phase one and two of the tests involved the determination of the median lethal dose for these chemicals and the third phase involved the reproductive effects study. Monoethanolamine, administered at 850 mg/kg/day, was toxic to pregnant animals causing a 16% mortality. Monoethanolamine reduced the number of viable litters but did not affect litter size, the percent survival of the pups, the birth weight of the pups or the weight gained by the pups. Diethanolamine, administered at 1125 mg/kg/day, caused no change in maternal mortality, number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. Triethanolamine, administered at 1125 mg/kg/day, did not affect maternal mortality, the number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups.
Keywords	Ethanolamine Toxicology Reproduction(Biology) Tables(Data) Industrial hygiene Mice Experimental design Exposure Public health Laboratory animals Lethal dosage Lubricants Monoethanolamine Diethanolamine Triethanolamine Toxic substances Screening Teratogenesis CAS 141-43-5 CAS 111-42-2 CAS 102-71-6 Body weight Maternal mortality Fetal death Occupational safety and health Dose-response relationships
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment 94D - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB89-139059. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735

Screening of Priority Chemicals for Reproductive Hazards. Monoethanolamine (Cas. No. 141-43-5); Diethanolamine (Cas. No. 111-42-2); Triethanolamine (Cas. No. 102-71-6).

Screening of Priority Chemicals for Reproductive Hazards. Monoethanolamine (Cas. No. 141-43-5); Diethanolamine (Cas. No. 111-42-2); Triethanolamine (Cas. No. 102-71-6).
PB89139067

Publication Date	1987
Page Count	64
Abstract	Monoethanolamine (141435), diethanolamine (111422), and triethanolamine (102716) were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Phase one and two of the tests involved the determination of the median lethal dose for these chemicals and the third phase involved the reproductive effects study. Monoethanolamine, administered at 850 mg/kg/day, was toxic to pregnant animals causing a 16% mortality. Monoethanolamine reduced the number of viable litters but did not affect litter size, the percent survival of the pups, the birth weight of the pups or the weight gained by the pups. Diethanolamine, administered at 1125 mg/kg/day, caused no change in maternal mortality, number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. Triethanolamine, administered at 1125 mg/kg/day, did not affect maternal mortality, the number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups.
Keywords	Ethanolamine Toxicology Reproduction(Biology) Tables(Data) Industrial hygiene Mice Experimental design Exposure Public health Laboratory animals Lethal dosage Lubricants Monoethanolamine Diethanolamine Triethanolamine Toxic substances Screening Teratogenesis CAS 141-43-5 CAS 111-42-2 CAS 102-71-6 Body weight Maternal mortality Fetal death Occupational safety and health Dose-response relationships
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment 94D - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB89-139059. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735