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Screening of Priority Chemicals for Reproductive Hazards. Benzyl Alcohol (Cas. No. 100-51-6); Probenecid (Cas. No. 57-66-9); Trans-Retinoic Acid (Cas. No. 302-79-4).

PB89139059

Publication Date	1986
Page Count	64
Abstract	Selected chemicals were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Attempts were made to determine the median lethal dose to be used and reproductive effects were monitored. Treatments were administered by gavage on gestation days 6 through 15. Probenecid (57669) at 1300 mg/kg/day was toxic to some maternal animals. Benzyl-alcohol (100516) and all trans-retinoic-acid (302794) doses produced no treatment related deaths in maternal animals. Benzyl-alcohol and probenecid caused no significant changes in maternal weight. The predicted median lethal dose for benzyl-alcohol was 550 mg/kg/day and that for probenecid was 1300 mg/kg/day. Neither chemical had a significant effect on the gestation index, reproductive index, maternal status, litter size or postnatal survival, average litter weight or weight gain among the pups. Neither chemical produced any evidence of developmental toxicity despite the maternal mortality caused by probenecid.
Keywords	Toxicology Reproduction(Biology) Benzyl alcohols Tables(Data) Industrial hygiene Mice Experimental design Exposure Public health Laboratory animals Solvents Lethal dosage Probenecid Tretinoin Toxic substances Screening Dose-response relationships CAS 100-51-6 CAS 57-66-9 CAS 302-79-4 Body weight Maternal mortality Fetal death Teratogenesis Occupational safety and health
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735

Screening of Priority Chemicals for Reproductive Hazards. Benzyl Alcohol (Cas. No. 100-51-6); Probenecid (Cas. No. 57-66-9); Trans-Retinoic Acid (Cas. No. 302-79-4).

Screening of Priority Chemicals for Reproductive Hazards. Benzyl Alcohol (Cas. No. 100-51-6); Probenecid (Cas. No. 57-66-9); Trans-Retinoic Acid (Cas. No. 302-79-4).
PB89139059

Publication Date	1986
Page Count	64
Abstract	Selected chemicals were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Attempts were made to determine the median lethal dose to be used and reproductive effects were monitored. Treatments were administered by gavage on gestation days 6 through 15. Probenecid (57669) at 1300 mg/kg/day was toxic to some maternal animals. Benzyl-alcohol (100516) and all trans-retinoic-acid (302794) doses produced no treatment related deaths in maternal animals. Benzyl-alcohol and probenecid caused no significant changes in maternal weight. The predicted median lethal dose for benzyl-alcohol was 550 mg/kg/day and that for probenecid was 1300 mg/kg/day. Neither chemical had a significant effect on the gestation index, reproductive index, maternal status, litter size or postnatal survival, average litter weight or weight gain among the pups. Neither chemical produced any evidence of developmental toxicity despite the maternal mortality caused by probenecid.
Keywords	Toxicology Reproduction(Biology) Benzyl alcohols Tables(Data) Industrial hygiene Mice Experimental design Exposure Public health Laboratory animals Solvents Lethal dosage Probenecid Tretinoin Toxic substances Screening Dose-response relationships CAS 100-51-6 CAS 57-66-9 CAS 302-79-4 Body weight Maternal mortality Fetal death Teratogenesis Occupational safety and health
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 68A - Air Pollution & Control 94D - Job Environment 41I - Job Environment
Corporate Authors	Environmental Health Research and Testing, Inc., Cincinnati, OH.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198909
Contract Number	PHS-NIOSH-200-84-2735