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Principles of Skin Permeability Relevant to Chemical Exposure,

PB89130009

Publication Date	1987
Personal Author	Guy, R. H.; Hadgraft, J.
Page Count	58
Abstract	Biological and physiochemical parameters which determine the rate and extent of chemical penetration across the human skin were identified. Such exposures may represent a significant occupational hazard. Anatomical features of the skin that control the barrier to absorption were reviewed. The interactions of the physiological parameters with the physicochemical properties of the dermally contacting chemical determine the kinetics and degree of penetration were discussed. The relationship between chemical structure and activity and penetration of the skin was reviewed for n-alkanols, phenols, phenylboronic acids, steroids, nicotinic acid esters, alkanoic acids, polynuclear aromatics, and nonsteroidal anti-inflammatory drugs. Using skin absorption data for the forearm alone it is possible to calculate relative body exposures; to model the process of skin absorption effectively is a complex undertaking. The simplest treatment involves the use of Fick's laws of diffusion and an estimation of total body burden following a dermal exposure. Another approach based on the physicochemical properties of the penetrant was also discussed.
Keywords	Skin absorption Hazardous materials Toxicology Organic compounds Biological transport Exposure Diffusion Metabolism Mathematical models Occupational safety and health Structure activity relationships
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57S - Physiology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 41I - Job Environment 94D - Job Environment
Corporate Authors	California Univ., San Francisco.; National Inst. for Occupational Safety and Health, Cincinnati, OH.; University of Wales Inst. of Science and Technology, Cardiff.
Supplemental Notes	Prepared in cooperation with University of Wales Inst. of Science and Technology, Cardiff. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198906

Principles of Skin Permeability Relevant to Chemical Exposure,

Principles of Skin Permeability Relevant to Chemical Exposure,
PB89130009

Publication Date	1987
Personal Author	Guy, R. H.; Hadgraft, J.
Page Count	58
Abstract	Biological and physiochemical parameters which determine the rate and extent of chemical penetration across the human skin were identified. Such exposures may represent a significant occupational hazard. Anatomical features of the skin that control the barrier to absorption were reviewed. The interactions of the physiological parameters with the physicochemical properties of the dermally contacting chemical determine the kinetics and degree of penetration were discussed. The relationship between chemical structure and activity and penetration of the skin was reviewed for n-alkanols, phenols, phenylboronic acids, steroids, nicotinic acid esters, alkanoic acids, polynuclear aromatics, and nonsteroidal anti-inflammatory drugs. Using skin absorption data for the forearm alone it is possible to calculate relative body exposures; to model the process of skin absorption effectively is a complex undertaking. The simplest treatment involves the use of Fick's laws of diffusion and an estimation of total body burden following a dermal exposure. Another approach based on the physicochemical properties of the penetrant was also discussed.
Keywords	Skin absorption Hazardous materials Toxicology Organic compounds Biological transport Exposure Diffusion Metabolism Mathematical models Occupational safety and health Structure activity relationships
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57S - Physiology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 41I - Job Environment 94D - Job Environment
Corporate Authors	California Univ., San Francisco.; National Inst. for Occupational Safety and Health, Cincinnati, OH.; University of Wales Inst. of Science and Technology, Cardiff.
Supplemental Notes	Prepared in cooperation with University of Wales Inst. of Science and Technology, Cardiff. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198906