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Cutaneous Responses to Topical Methyl Nicotinate in Black, Oriental and Caucasian Subjects,

PB89129910

Publication Date	1987
Personal Author	Gean, C. J.; Tur, E.; Maibach, H. I.; Guy, R. H.
Page Count	28
Abstract	Assessments were made of cutaneous responses to topically applied methyl-nicotinate (93607) (MN) on black, oriental, and Caucasian subjects to determine if racial differences had any part to play in percutaneous absorption and microcirculatory sensitivity. Both visual and laser Doppler velocimetry evaluations were made of the MN induced vasodilatation. Specific assessment was made of the diameter of the maximum visually perceptible erythematous area, the area under the erythematous diameter versus time curve, the maximum laser Doppler velocimetry response, and the area under the laser Doppler velocimetry response versus time curve. For all subjects each of the measures was dependent on the dose of MN applied with the exception of the maximum laser Doppler velocimetry response. The authors conclude that although some racial differences did appear to exist in response to topical MN, the perception of these distinctions may depend on the method of measurement.
Keywords	Skin absorption Toxicity Racial stocks Dermatology Exposure Vasodilation Mongoloid race Caucasoid race Negroid race Nitrogen heterocyclic compounds Concentration(Composition) Methyl nicotinate Pyridine carboxylic acid/(methyl ester) CAS 93-60-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57S - Physiology 57Q - Pharmacology & Pharmacological Chemistry 57Y - Toxicology
Corporate Authors	California Univ., San Francisco.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198906

Cutaneous Responses to Topical Methyl Nicotinate in Black, Oriental and Caucasian Subjects,

Cutaneous Responses to Topical Methyl Nicotinate in Black, Oriental and Caucasian Subjects,
PB89129910

Publication Date	1987
Personal Author	Gean, C. J.; Tur, E.; Maibach, H. I.; Guy, R. H.
Page Count	28
Abstract	Assessments were made of cutaneous responses to topically applied methyl-nicotinate (93607) (MN) on black, oriental, and Caucasian subjects to determine if racial differences had any part to play in percutaneous absorption and microcirculatory sensitivity. Both visual and laser Doppler velocimetry evaluations were made of the MN induced vasodilatation. Specific assessment was made of the diameter of the maximum visually perceptible erythematous area, the area under the erythematous diameter versus time curve, the maximum laser Doppler velocimetry response, and the area under the laser Doppler velocimetry response versus time curve. For all subjects each of the measures was dependent on the dose of MN applied with the exception of the maximum laser Doppler velocimetry response. The authors conclude that although some racial differences did appear to exist in response to topical MN, the perception of these distinctions may depend on the method of measurement.
Keywords	Skin absorption Toxicity Racial stocks Dermatology Exposure Vasodilation Mongoloid race Caucasoid race Negroid race Nitrogen heterocyclic compounds Concentration(Composition) Methyl nicotinate Pyridine carboxylic acid/(methyl ester) CAS 93-60-7
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57S - Physiology 57Q - Pharmacology & Pharmacological Chemistry 57Y - Toxicology
Corporate Authors	California Univ., San Francisco.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198906