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Potential Indirect Mechanisms of Carcinogenesis: A Preliminary Taxonomy,

PB89120513

Publication Date	1986
Personal Author	Hattis, D.; Strauss, H.
Page Count	93
Abstract	A preliminary taxonomy of possible indirect mechanisms by which chemicals might increase the incidence of tumors was presented. Indirect processes that can increase the frequency of observed tumors were listed including changes in basic transport processes, changes in metabolic processing, changes in the effective amount of target DNA for reaction, and changes in the efficiency of repair of initial DNA lesions. Indirect processes that alter the frequency with which initiated cells progress through subsequent stages in the carcinogenic process were discussed, including the induction of subsequent genetic changes along the pathway to carcinogenesis, changes in the removal of initiated cells by terminal differentiation, the release of initiated cells from growth control by neighboring cells, and changes in the rates of proliferation or survival of initiated cells relative to the proliferation of normal cells. Indirect processes that might change the survival, growth, and spread of tumors or the progression of tumors included changes in hormonally mediated processes that speed up growth of specific cell types, changes in the efficiency of immune surveillance, and changes in local tissue conditions that favor colonization of new tissues by metastases.
Keywords	Carcinogens Mutagens Deoxyribonucleic acids Cells(Biology) Risk assessment DNA repair Cell differentiation Cell division
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57F - Cytology, Genetics, & Molecular Biology
Corporate Authors	Massachusetts Inst. of Tech., Cambridge. Center for Technology, Policy and Industrial Development.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198903

Potential Indirect Mechanisms of Carcinogenesis: A Preliminary Taxonomy,

Potential Indirect Mechanisms of Carcinogenesis: A Preliminary Taxonomy,
PB89120513

Publication Date	1986
Personal Author	Hattis, D.; Strauss, H.
Page Count	93
Abstract	A preliminary taxonomy of possible indirect mechanisms by which chemicals might increase the incidence of tumors was presented. Indirect processes that can increase the frequency of observed tumors were listed including changes in basic transport processes, changes in metabolic processing, changes in the effective amount of target DNA for reaction, and changes in the efficiency of repair of initial DNA lesions. Indirect processes that alter the frequency with which initiated cells progress through subsequent stages in the carcinogenic process were discussed, including the induction of subsequent genetic changes along the pathway to carcinogenesis, changes in the removal of initiated cells by terminal differentiation, the release of initiated cells from growth control by neighboring cells, and changes in the rates of proliferation or survival of initiated cells relative to the proliferation of normal cells. Indirect processes that might change the survival, growth, and spread of tumors or the progression of tumors included changes in hormonally mediated processes that speed up growth of specific cell types, changes in the efficiency of immune surveillance, and changes in local tissue conditions that favor colonization of new tissues by metastases.
Keywords	Carcinogens Mutagens Deoxyribonucleic acids Cells(Biology) Risk assessment DNA repair Cell differentiation Cell division
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57F - Cytology, Genetics, & Molecular Biology
Corporate Authors	Massachusetts Inst. of Tech., Cambridge. Center for Technology, Policy and Industrial Development.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198903