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Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,


PB88248000

Publication Date 1980
Personal Author Altenkirch, H.; Wagner, H. M.; Stoltenburg, G.; Spencer, P. S.
Page Count 26
Abstract The nervous system effects of continuous inhalation exposures to concentrations of n-hexane (110543) (HEX) or HEX plus methyl-ethyl-ketone (78933) (MEK) mixtures were investigated in male Wistar-rats. Long term effects of intermittent exposures to the mixtures were also examined in experiment-B. Solvent exposed animals from experiment-A showed marked reductions in weight. Those treated with the mixture of compounds demonstrated excessive hypersalivation, frequent orange/red discoloration of the skin and fur, and narcosis. All solvent exposed animals demonstrated limb weakness commencing by evasion of the hindlimbs and resulting in paralysis. Histological examination showed, axonal lesions in peripheral nerves, and in the gracile tract at cervical levels of the spinal cord. Those who survived experiment-B did not give evidence of narcosis and no depressed body weights were evident. Fur discoloration was restricted to an orange/red collar around the neck and appeared more often in animals exposed to the mixture than to hexane alone.
Keywords
  • Hexanes
  • Methyl ethyl ketone
  • Toxicity
  • Solvents
  • Respiration
  • Exposure
  • Laboratory animals
  • Mixtures
  • Pathology
  • Nervous systems
  • Ketones
  • Aliphatic hydrocarbons
  • Occupational health and safety
  • Toxic substances
  • Drug synergism
  • CAS 110-54-3
  • CAS 78-93-3
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 41I - Job Environment
  • 68G - Environmental Health & Safety
  • 94D - Job Environment
Corporate Authors Freie Univ. Berlin (Germany, F.R.). Klinikum Steglitz.; Albert Einstein Coll. of Medicine, Bronx, NY.; Bundesgesundheitsamt, Berlin (Germany, F.R.).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Prepared in cooperation with Bundesgesundheitsamt, Berlin (Germany, F.R.), and Albert Einstein Coll. of Medicine, Bronx, NY. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198824
Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,
Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,
PB88248000

  • Hexanes
  • Methyl ethyl ketone
  • Toxicity
  • Solvents
  • Respiration
  • Exposure
  • Laboratory animals
  • Mixtures
  • Pathology
  • Nervous systems
  • Ketones
  • Aliphatic hydrocarbons
  • Occupational health and safety
  • Toxic substances
  • Drug synergism
  • CAS 110-54-3
  • CAS 78-93-3
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57U - Public Health & Industrial Medicine
  • 41I - Job Environment
  • 68G - Environmental Health & Safety
  • 94D - Job Environment
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