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Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,

PB88248000

Publication Date	1980
Personal Author	Altenkirch, H.; Wagner, H. M.; Stoltenburg, G.; Spencer, P. S.
Page Count	26
Abstract	The nervous system effects of continuous inhalation exposures to concentrations of n-hexane (110543) (HEX) or HEX plus methyl-ethyl-ketone (78933) (MEK) mixtures were investigated in male Wistar-rats. Long term effects of intermittent exposures to the mixtures were also examined in experiment-B. Solvent exposed animals from experiment-A showed marked reductions in weight. Those treated with the mixture of compounds demonstrated excessive hypersalivation, frequent orange/red discoloration of the skin and fur, and narcosis. All solvent exposed animals demonstrated limb weakness commencing by evasion of the hindlimbs and resulting in paralysis. Histological examination showed, axonal lesions in peripheral nerves, and in the gracile tract at cervical levels of the spinal cord. Those who survived experiment-B did not give evidence of narcosis and no depressed body weights were evident. Fur discoloration was restricted to an orange/red collar around the neck and appeared more often in animals exposed to the mixture than to hexane alone.
Keywords	Hexanes Methyl ethyl ketone Toxicity Solvents Respiration Exposure Laboratory animals Mixtures Pathology Nervous systems Ketones Aliphatic hydrocarbons Occupational health and safety Toxic substances Drug synergism CAS 110-54-3 CAS 78-93-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 41I - Job Environment 68G - Environmental Health & Safety 94D - Job Environment
Corporate Authors	Freie Univ. Berlin (Germany, F.R.). Klinikum Steglitz.; Albert Einstein Coll. of Medicine, Bronx, NY.; Bundesgesundheitsamt, Berlin (Germany, F.R.).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Bundesgesundheitsamt, Berlin (Germany, F.R.), and Albert Einstein Coll. of Medicine, Bronx, NY. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198824

Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,

Nervous-System Responses of Rats to Subchronic Inhalation of n-Hexane and n-Hexane + Methyl-Ethyl-Ketone Mixtures,
PB88248000

Publication Date	1980
Personal Author	Altenkirch, H.; Wagner, H. M.; Stoltenburg, G.; Spencer, P. S.
Page Count	26
Abstract	The nervous system effects of continuous inhalation exposures to concentrations of n-hexane (110543) (HEX) or HEX plus methyl-ethyl-ketone (78933) (MEK) mixtures were investigated in male Wistar-rats. Long term effects of intermittent exposures to the mixtures were also examined in experiment-B. Solvent exposed animals from experiment-A showed marked reductions in weight. Those treated with the mixture of compounds demonstrated excessive hypersalivation, frequent orange/red discoloration of the skin and fur, and narcosis. All solvent exposed animals demonstrated limb weakness commencing by evasion of the hindlimbs and resulting in paralysis. Histological examination showed, axonal lesions in peripheral nerves, and in the gracile tract at cervical levels of the spinal cord. Those who survived experiment-B did not give evidence of narcosis and no depressed body weights were evident. Fur discoloration was restricted to an orange/red collar around the neck and appeared more often in animals exposed to the mixture than to hexane alone.
Keywords	Hexanes Methyl ethyl ketone Toxicity Solvents Respiration Exposure Laboratory animals Mixtures Pathology Nervous systems Ketones Aliphatic hydrocarbons Occupational health and safety Toxic substances Drug synergism CAS 110-54-3 CAS 78-93-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 41I - Job Environment 68G - Environmental Health & Safety 94D - Job Environment
Corporate Authors	Freie Univ. Berlin (Germany, F.R.). Klinikum Steglitz.; Albert Einstein Coll. of Medicine, Bronx, NY.; Bundesgesundheitsamt, Berlin (Germany, F.R.).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Prepared in cooperation with Bundesgesundheitsamt, Berlin (Germany, F.R.), and Albert Einstein Coll. of Medicine, Bronx, NY. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198824