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Methyl Methacrylate Induced Changes in CNS (Central Nervous System) Activity.

PB88247648

Publication Date	1980
Personal Author	Innes, D. L.
Page Count	12
Abstract	Experiments were performed to determine if methyl-methacrylate (80626) (MMA) monomer vapor in air caused central nervous system (CNS) changes in exposed rats. Rats were exposed to 400 parts per million (ppm) MMA vapor for 60 minutes. The only significant changes occurred in the lateral hypothalamic and ventral hippocampal nuclei. Several substudies suggested that the changes in the hippocampal neuronal firing rates were related to the perception of the MMA odor and dependent on an intact nervous connection to the receptors in the nose. In a subchronic study no consistent long term changes in neuronal activity were detected. However, a decrease in neuronal activity was detected during the first week of exposure. In another study the exposure levels of MMA ranged from 50 to 800 ppm. The lateral hypothalamic and ventral hippocampal nuclei responded as before, but not at the 50 ppm level. The author concludes that the threshold exposure concentration for the observed effects are the same as or slightly less than the current threshold limit value for MMA vapor in the workplace.
Keywords	Methacrylates Toxicity Concentration(Composition) Exposure Carboxylic acid esters Toxicology Laboratory animals Respiration Vapors Hippocampus Hypothalamus Nervous system disorders Hazardous materials Plastics industry Methyl methacrylate Occupational safety and health Toxic substances
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors
Corporate Authors	Temple Univ., Philadelphia, PA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	1 Mar 78-28 Feb 80,
NTIS Issue Number	198823

Methyl Methacrylate Induced Changes in CNS (Central Nervous System) Activity.

Methyl Methacrylate Induced Changes in CNS (Central Nervous System) Activity.
PB88247648

Publication Date	1980
Personal Author	Innes, D. L.
Page Count	12
Abstract	Experiments were performed to determine if methyl-methacrylate (80626) (MMA) monomer vapor in air caused central nervous system (CNS) changes in exposed rats. Rats were exposed to 400 parts per million (ppm) MMA vapor for 60 minutes. The only significant changes occurred in the lateral hypothalamic and ventral hippocampal nuclei. Several substudies suggested that the changes in the hippocampal neuronal firing rates were related to the perception of the MMA odor and dependent on an intact nervous connection to the receptors in the nose. In a subchronic study no consistent long term changes in neuronal activity were detected. However, a decrease in neuronal activity was detected during the first week of exposure. In another study the exposure levels of MMA ranged from 50 to 800 ppm. The lateral hypothalamic and ventral hippocampal nuclei responded as before, but not at the 50 ppm level. The author concludes that the threshold exposure concentration for the observed effects are the same as or slightly less than the current threshold limit value for MMA vapor in the workplace.
Keywords	Methacrylates Toxicity Concentration(Composition) Exposure Carboxylic acid esters Toxicology Laboratory animals Respiration Vapors Hippocampus Hypothalamus Nervous system disorders Hazardous materials Plastics industry Methyl methacrylate Occupational safety and health Toxic substances
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 44G - Environmental & Occupational Factors
Corporate Authors	Temple Univ., Philadelphia, PA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	1 Mar 78-28 Feb 80,
NTIS Issue Number	198823