| Abstract |
Efforts were directed toward characterizing worker exposure to 4,4'-methylene-dianiline (101779) (4,4'-MDA) and evaluating the usefulness of collecting worker urine samples to assess exposure to 4,4'-MDA on the job. A review of pharmacokinetic studies was included, along with considerations of importance in biological monitoring, study site and worker selection factors, identification of biological variables, choosing a nonexposed comparison group, survey procedures, sampling methods, environmental sampling techniques, urinalysis methods and sample collection and processing, analytical procedures used for the air, wipe, and dermal samples, statistical methods used for the field data analysis, quality assurance procedures, safety of the investigators during the study, records management and data reporting. |
