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Pathomechanisms of Chemically Induced Depigmentation,


PB88247077

Publication Date 1983
Personal Author Gellin, G. A.
Page Count 11
Abstract Analyses were made of skin from albino-mice, pigmented-mice, and melanoma cells. System-A detects DOPA, cysteinyldopas and related compounds. The melanoma cells demonstrated six peaks, pigmented ear skin showed four and albino ear skin only one. Using system-B, which detects indole derivatives, two peaks were observed. Butylated-hydroxytoluene (BHT) was added to the food given to mice. Four weeks after feeding BHT the pigment was sparse and irregular. Electron microscopy studies were carried out on human skin from patients before and after treatment with PUVA. After 2 weeks of treatment many melanosomes demonstrated irregular deposition of pigment which was ultrastructurally interpreted as the start of pheomelanogenesis. Skin biopsy of a black woman with depigmentation who wore rubber gloves while working at a hotel showed no melanocytes. Tests revealed melanosomes with a pheomelanogenesis-like ultrastructure. The author concludes that the basic methods needed to investigate chemically induced depigmentation have been developed.
Keywords
  • Occupational diseases
  • Pigments
  • Chromatographic analysis
  • Melanoma
  • Exposure
  • Antioxidants
  • Laboratory animals
  • Chemical analysis
  • Ultraviolet radiation
  • Enzymes
  • Skin pigmentation
  • Pigmentation disorders
  • Occupational safety and health
  • Melanocytes
  • Butylated hydroxytoluene
  • Phenol/bis(dimethyl)-methyl)
  • Benzenediol/dimethylethyl
  • PUVA therapy
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57O - Pathology
  • 57E - Clinical Medicine
  • 99A - Analytical Chemistry
Corporate Authors National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198823
Pathomechanisms of Chemically Induced Depigmentation,
Pathomechanisms of Chemically Induced Depigmentation,
PB88247077

  • Occupational diseases
  • Pigments
  • Chromatographic analysis
  • Melanoma
  • Exposure
  • Antioxidants
  • Laboratory animals
  • Chemical analysis
  • Ultraviolet radiation
  • Enzymes
  • Skin pigmentation
  • Pigmentation disorders
  • Occupational safety and health
  • Melanocytes
  • Butylated hydroxytoluene
  • Phenol/bis(dimethyl)-methyl)
  • Benzenediol/dimethylethyl
  • PUVA therapy
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57O - Pathology
  • 57E - Clinical Medicine
  • 99A - Analytical Chemistry
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