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Acrylonitrile Pharmacodynamics and Mutagenesis.


PB88246947

Publication Date 1979
Personal Author Wolff, M. S.
Page Count 10
Abstract A study was made of the pharmacokinetics of acrylonitrile (107131) (AN) with emphasis on routes of elimination and mechanisms of metabolism. Rats were given intraperitoneal injections of AN at 5 to 60mg/kg. Two AN analogues, crotononitrile (4786203) (CN) and methacrylonitrile (126987) (MN), were also studied. CN and MN concentrations in blood followed a first order kinetic elimination. AN demonstrated a biphasic kinetic elimination. AN was measurable in fat, liver and blood for 18 hours after a 37mg/kg dose. Fecal excretion was significant at levels of 3 to 9 parts per million (ppm) at 3 hours after exposure. Urine levels of 0.03ppm were registered after 5.3mg/kg dose levels and 0.1ppm after 81mg/kg. Total AN in feces, urine and tissues even at very short intervals after intraperitoneal administration represented only 3 to 30 percent of the administered dose. The fast AN metabolic pathway was consistent with Michael addition to AN or its analogs and would readily account for cyanide formation.
Keywords
  • Acrylonitriles
  • Methacrylonitrile
  • Laboratory animals
  • Metabolism
  • Nitriles
  • Excretion
  • Liver
  • Crotononitrile
  • Toxic substances
  • Tissue distribution
  • Pharmacokinetics
  • Adipose tissue
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Q - Pharmacology & Pharmacological Chemistry
  • 57Y - Toxicology
Corporate Authors Mount Sinai School of Medicine, New York. Environmental Sciences Lab.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
Title Note Rept. for 1 Jul 77-30 Jun 79,
NTIS Issue Number 198823
Acrylonitrile Pharmacodynamics and Mutagenesis.
Acrylonitrile Pharmacodynamics and Mutagenesis.
PB88246947

  • Acrylonitriles
  • Methacrylonitrile
  • Laboratory animals
  • Metabolism
  • Nitriles
  • Excretion
  • Liver
  • Crotononitrile
  • Toxic substances
  • Tissue distribution
  • Pharmacokinetics
  • Adipose tissue
  • National Institute for Occupational Safety and Health
  • 57Q - Pharmacology & Pharmacological Chemistry
  • 57Y - Toxicology
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