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Influence of Exposure History on Mercury Excretion.

PB88240197

Publication Date	1973
Personal Author	Cember, H.
Page Count	56
Abstract	Determination of whether the size of a dose of a given mercurial influences the kinetics of distribution and elimination of the mercury was the objective of the research. Great differences in urinary mercury output have been observed among workers of the same group. Results of the study are considered applicable to strengthening the scientific basis for the bioassay monitoring portion of the occupational health surveillance program designed to prevent damage to exposed workers. The dose dependence of elimination kinetics is studied by injecting labeled mercury at various dose levels into rabbits and rats, measuring the elimination from the animal directly by total body counting techniques and indirectly by analysis of the daily urine and feces output of each animal.
Keywords	Mercury poisoning Toxicology Heavy metal excretion Laboratory animals Dosage Exposure Occupational safety and health Toxic substances Pharmacokinetics
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57S - Physiology 57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	Northwestern Univ., Evanston, IL. Technological Inst.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198823

Influence of Exposure History on Mercury Excretion.

Influence of Exposure History on Mercury Excretion.
PB88240197

Publication Date	1973
Personal Author	Cember, H.
Page Count	56
Abstract	Determination of whether the size of a dose of a given mercurial influences the kinetics of distribution and elimination of the mercury was the objective of the research. Great differences in urinary mercury output have been observed among workers of the same group. Results of the study are considered applicable to strengthening the scientific basis for the bioassay monitoring portion of the occupational health surveillance program designed to prevent damage to exposed workers. The dose dependence of elimination kinetics is studied by injecting labeled mercury at various dose levels into rabbits and rats, measuring the elimination from the animal directly by total body counting techniques and indirectly by analysis of the daily urine and feces output of each animal.
Keywords	Mercury poisoning Toxicology Heavy metal excretion Laboratory animals Dosage Exposure Occupational safety and health Toxic substances Pharmacokinetics
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57S - Physiology 57U - Public Health & Industrial Medicine 57Y - Toxicology
Corporate Authors	Northwestern Univ., Evanston, IL. Technological Inst.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198823