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Summary Review of the Health Effects Associated with Sodium Hydroxide: Health Issue Assessment,

PB88231949

Publication Date	1988
Personal Author	Martin, F. M.
Page Count	46
Abstract	Sodium hydroxide (NaOH) is produced in large quantities in the U.S. and the aerosol may be rebased into the atmosphere. Inhalation of aerosolized NaOH can cause damage to the upper respiratory tract and to the lungs. Rats exposed to a 40% NaOH aerosol in a chronic study showed bronchial ulceration and necrosis. At 20%, bronchi were dilated and the epithelium was desquamated. Irritation may occur at air concentrations below 2mg/cu m. NaOH was shown to be not genotoxic by the Ames reversion test and DNA-repair test. NaOH was found to be not teratogenic in mice. NaOH was classified as Class D as to carcinogenicity.
Keywords	Air pollution Sodium hydroxide Toxicology Aerosols Laboratory animals Rats Mice Carcinogens Respiratory diseases Reproduction(Biology) Exposure Concentration(Composition) Carcinogenesis Toxic substances Environmental health Health effects Inhalation Pharmacokinetics Mutagenicity Air quality
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine 68A - Air Pollution & Control
Corporate Authors	Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.; Oak Ridge National Lab., TN. Information Research and Analysis Div.
Supplemental Notes	Prepared in cooperation with Oak Ridge National Lab., TN. Information Research and Analysis Div.
Document Type	Technical Report
NTIS Issue Number	198820

Summary Review of the Health Effects Associated with Sodium Hydroxide: Health Issue Assessment,

Summary Review of the Health Effects Associated with Sodium Hydroxide: Health Issue Assessment,
PB88231949

Publication Date	1988
Personal Author	Martin, F. M.
Page Count	46
Abstract	Sodium hydroxide (NaOH) is produced in large quantities in the U.S. and the aerosol may be rebased into the atmosphere. Inhalation of aerosolized NaOH can cause damage to the upper respiratory tract and to the lungs. Rats exposed to a 40% NaOH aerosol in a chronic study showed bronchial ulceration and necrosis. At 20%, bronchi were dilated and the epithelium was desquamated. Irritation may occur at air concentrations below 2mg/cu m. NaOH was shown to be not genotoxic by the Ames reversion test and DNA-repair test. NaOH was found to be not teratogenic in mice. NaOH was classified as Class D as to carcinogenicity.
Keywords	Air pollution Sodium hydroxide Toxicology Aerosols Laboratory animals Rats Mice Carcinogens Respiratory diseases Reproduction(Biology) Exposure Concentration(Composition) Carcinogenesis Toxic substances Environmental health Health effects Inhalation Pharmacokinetics Mutagenicity Air quality
Source Agency	Environmental Protection Agency Office of Research and Development
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine 68A - Air Pollution & Control
Corporate Authors	Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.; Oak Ridge National Lab., TN. Information Research and Analysis Div.
Supplemental Notes	Prepared in cooperation with Oak Ridge National Lab., TN. Information Research and Analysis Div.
Document Type	Technical Report
NTIS Issue Number	198820