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Rat Oral Subchronic Toxicity Study. Compound: Isobutyl Alcohol.

PB88176177

Publication Date	1987
Personal Author	Tompkins, E. C.
Page Count	406
Abstract	The purpose of the study was to evaluate the toxicity of isobutyl alcohol in a rat subchronic toxicity study. Four groups of male and female rats (30/sex/group) were dosed orally once daily with 0, 100, 316, or 1000 mg/kg/day of compound until the day of necropsy at an interim sacrifice (days 29 and 30) or a final sacrifice (days 92 and 93). Oral administration of isobutyl alcohol produced treatment-related effects at a dose level of 1000 mg/kg/day, but not at dose levels of 100 or 316 mg/kg/day. At the 1000 mg/kg/day dose level, hypoactivity was observed in all rats and body weight gain in the males was 18% below the control average during week 1. Food consumption averages were below those of the controls for both males and females during weeks 1 and 2. In addition, serum potassium averages were 11-15% below control averages (both sexes) at the interim evaluation and this may have been a small transitory effect related to treatment.
Keywords	Toxicology Bioassay Rats Laboratory animals Ingestion(Biology) Dosage Isobutyl alcohol Teratogenesis CAS 78-83-1
Source Agency	Office of Solid Waste
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Solid Waste.; Toxicity Research Labs. Ltd., Muskegon, MI.
Supplemental Notes	Also pub. as Toxicity Research Labs., Ltd., Muskegon, MI. rept. no. TRL/STUDY-032-002. Prepared in cooperation with Toxicity Research Labs. Ltd., Muskegon, MI. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198811
Contract Number	EPA-68-01-7075

Rat Oral Subchronic Toxicity Study. Compound: Isobutyl Alcohol.

Rat Oral Subchronic Toxicity Study. Compound: Isobutyl Alcohol.
PB88176177

Publication Date	1987
Personal Author	Tompkins, E. C.
Page Count	406
Abstract	The purpose of the study was to evaluate the toxicity of isobutyl alcohol in a rat subchronic toxicity study. Four groups of male and female rats (30/sex/group) were dosed orally once daily with 0, 100, 316, or 1000 mg/kg/day of compound until the day of necropsy at an interim sacrifice (days 29 and 30) or a final sacrifice (days 92 and 93). Oral administration of isobutyl alcohol produced treatment-related effects at a dose level of 1000 mg/kg/day, but not at dose levels of 100 or 316 mg/kg/day. At the 1000 mg/kg/day dose level, hypoactivity was observed in all rats and body weight gain in the males was 18% below the control average during week 1. Food consumption averages were below those of the controls for both males and females during weeks 1 and 2. In addition, serum potassium averages were 11-15% below control averages (both sexes) at the interim evaluation and this may have been a small transitory effect related to treatment.
Keywords	Toxicology Bioassay Rats Laboratory animals Ingestion(Biology) Dosage Isobutyl alcohol Teratogenesis CAS 78-83-1
Source Agency	Office of Solid Waste
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Solid Waste.; Toxicity Research Labs. Ltd., Muskegon, MI.
Supplemental Notes	Also pub. as Toxicity Research Labs., Ltd., Muskegon, MI. rept. no. TRL/STUDY-032-002. Prepared in cooperation with Toxicity Research Labs. Ltd., Muskegon, MI. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198811
Contract Number	EPA-68-01-7075