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90-Day Subchronic Oral Toxicity in Rats Test Material: Pyridine. Volume 1.

PB88176136

Publication Date	1987
Personal Author	Anderson, R. C.
Page Count	390
Abstract	Pyridine was identified by Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry. Assay by the above methods as well as gas chromatography with a flame ionization detector indicated that the material was greater than 99.9% pure throughout the duration of the study. Stability tests on aqueous solutions of pyridine in teflon sealed, amber glass bottles indicated the test material was stable and the concentration was unchanged over a period of up to 4 weeks. A specific objective of the study was to develop data on the neurological effects of pyridine over the period of exposure. No significant histopathological or clinical findings related to the neurological systems were found that could be definitely attributed to exposure to pyridine.
Keywords	Toxicology Bioassay Diets Rats Laboratory animals Ingestion(Biology) Pyridine Neurotoxicity CAS 11-086-1
Source Agency	Office of Solid Waste
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	Dynamac Corp., Rockville, MD.; Little (Arthur D.), Inc., Cambridge, MA.; Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Supplemental Notes	See also Volume 2, PB88-176144. Portions of this document are not fully legible. Prepared in cooperation with Little (Arthur D.), Inc., Cambridge, MA. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198811
Contract Number	EPA-68-01-7266

90-Day Subchronic Oral Toxicity in Rats Test Material: Pyridine. Volume 1.

90-Day Subchronic Oral Toxicity in Rats Test Material: Pyridine. Volume 1.
PB88176136

Publication Date	1987
Personal Author	Anderson, R. C.
Page Count	390
Abstract	Pyridine was identified by Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry. Assay by the above methods as well as gas chromatography with a flame ionization detector indicated that the material was greater than 99.9% pure throughout the duration of the study. Stability tests on aqueous solutions of pyridine in teflon sealed, amber glass bottles indicated the test material was stable and the concentration was unchanged over a period of up to 4 weeks. A specific objective of the study was to develop data on the neurological effects of pyridine over the period of exposure. No significant histopathological or clinical findings related to the neurological systems were found that could be definitely attributed to exposure to pyridine.
Keywords	Toxicology Bioassay Diets Rats Laboratory animals Ingestion(Biology) Pyridine Neurotoxicity CAS 11-086-1
Source Agency	Office of Solid Waste
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	Dynamac Corp., Rockville, MD.; Little (Arthur D.), Inc., Cambridge, MA.; Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Supplemental Notes	See also Volume 2, PB88-176144. Portions of this document are not fully legible. Prepared in cooperation with Little (Arthur D.), Inc., Cambridge, MA. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Document Type	Technical Report
Title Note	Final rept.,
NTIS Issue Number	198811
Contract Number	EPA-68-01-7266