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Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram (Revised Edition).

PB87234811

Publication Date	1980
Personal Author	Wong, L. C. K.; Winston, J. M.; Hong, C. B.; Hagensen, J.; Plotnick, H. B.
Page Count	40
Abstract	The effects of chronic exposure to 20 parts per million (ppm) 1,2-dibromoethane (106934) (EDB) were studied in Sprague-Dawley-rats. Male and female rats were exposed to EDB for 7 hours/day, 5 days/week for 18 months; some rats were also given a diet containing 0.05 percent disulfiram (97778). Administration of EDB with disulfiram resulted in most of the rats dying or being terminated during the first 12 months; all rats in the group died or were terminated by the fifteenth month. The group receiving EDB alone had higher mortality than a control group or a group receiving disulfiram alone. Body weight was depressed in the EDB/disulfiram group to a greater extent than in the EDB group. The EDB/disulfiram group showed a significant increase in the incidence of tumors of the liver and mesentery, compared to the group receiving EDB alone. EDB/disulfiram resulted in a tenfold increase in hepatocellular carcinoma, compared to EDB alone. Testicular atrophy was found in 88 percent of the EDB/disulfiram males, but in only 2 percent of EDB males.
Keywords	Toxicology Malignant neoplasms Respiration Rats Laboratory animals Air pollution Ingestion(Biology) Diets Lethal dosage Bioassay Fumes Ethane/dibromo Air pollution effects(Animals) Disulfiram Carcinogenesis Cancer Synergism CAS 106-93-4 CAS 97-77-8
Source Agency	Centers for Disease Control Bureau of Laboratories National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Revision of report dated Feb 79, PB82-195603. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
NTIS Issue Number	198724
Contract Number	PHS-NIOSH-210-76-0131

Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram (Revised Edition).

Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram (Revised Edition).
PB87234811

Publication Date	1980
Personal Author	Wong, L. C. K.; Winston, J. M.; Hong, C. B.; Hagensen, J.; Plotnick, H. B.
Page Count	40
Abstract	The effects of chronic exposure to 20 parts per million (ppm) 1,2-dibromoethane (106934) (EDB) were studied in Sprague-Dawley-rats. Male and female rats were exposed to EDB for 7 hours/day, 5 days/week for 18 months; some rats were also given a diet containing 0.05 percent disulfiram (97778). Administration of EDB with disulfiram resulted in most of the rats dying or being terminated during the first 12 months; all rats in the group died or were terminated by the fifteenth month. The group receiving EDB alone had higher mortality than a control group or a group receiving disulfiram alone. Body weight was depressed in the EDB/disulfiram group to a greater extent than in the EDB group. The EDB/disulfiram group showed a significant increase in the incidence of tumors of the liver and mesentery, compared to the group receiving EDB alone. EDB/disulfiram resulted in a tenfold increase in hepatocellular carcinoma, compared to EDB alone. Testicular atrophy was found in 88 percent of the EDB/disulfiram males, but in only 2 percent of EDB males.
Keywords	Toxicology Malignant neoplasms Respiration Rats Laboratory animals Air pollution Ingestion(Biology) Diets Lethal dosage Bioassay Fumes Ethane/dibromo Air pollution effects(Animals) Disulfiram Carcinogenesis Cancer Synergism CAS 106-93-4 CAS 97-77-8
Source Agency	Centers for Disease Control Bureau of Laboratories National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	Revision of report dated Feb 79, PB82-195603. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science.
Document Type	Technical Report
NTIS Issue Number	198724
Contract Number	PHS-NIOSH-210-76-0131