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NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.


PB87222865

Publication Date 1978
Page Count 34
Abstract Testimony was presented concerning the establishment of an occupational exposure standard for acrylonitrile (107131) (AN) to which an estimated 125,000 workers were potentially exposed. Two year feeding and inhalation studies with animals indicated the chemical to be carcinogenic, producing tumors of the central nervous system (CNS), cerebral tumors, squamous cell neoplasms of the Zymbal gland, adenocarcinoma of the small intestine and large intestine, along with numerous benign tumors. Other findings included papillomata in the stomach, hemangioma of the kidney, fibroadenomas of the mammary gland, benign tumors of the uterus, and tumors of the ear canal. Teratogenicity studies indicated increased incidence of fetal malformation. Cases of AN as an allergen causing contact dermatitis and ulcers have been widely documented. It was recommended that drugs essential to the treatment of acute intoxication from AN be kept in the medical facility of all facilities using AN, and that employers institute a respiratory protection program in accordance with requirements.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Acrylonitriles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Standards
  • Acrylic fibers
  • Nitriles
  • Cyanides
  • Toxic substances
  • Occupational safety and health
  • Testimony
  • Carcinogenesis
  • Indoor air pollution
  • CAS 107-13-1
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
Corporate Authors National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198724
NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.
NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.
PB87222865

  • Environmental surveys
  • Industrial medicine
  • Acrylonitriles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Standards
  • Acrylic fibers
  • Nitriles
  • Cyanides
  • Toxic substances
  • Occupational safety and health
  • Testimony
  • Carcinogenesis
  • Indoor air pollution
  • CAS 107-13-1
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
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