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NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.

PB87222865

Publication Date	1978
Page Count	34
Abstract	Testimony was presented concerning the establishment of an occupational exposure standard for acrylonitrile (107131) (AN) to which an estimated 125,000 workers were potentially exposed. Two year feeding and inhalation studies with animals indicated the chemical to be carcinogenic, producing tumors of the central nervous system (CNS), cerebral tumors, squamous cell neoplasms of the Zymbal gland, adenocarcinoma of the small intestine and large intestine, along with numerous benign tumors. Other findings included papillomata in the stomach, hemangioma of the kidney, fibroadenomas of the mammary gland, benign tumors of the uterus, and tumors of the ear canal. Teratogenicity studies indicated increased incidence of fetal malformation. Cases of AN as an allergen causing contact dermatitis and ulcers have been widely documented. It was recommended that drugs essential to the treatment of acute intoxication from AN be kept in the medical facility of all facilities using AN, and that employers institute a respiratory protection program in accordance with requirements.
Keywords	Environmental surveys Industrial medicine Acrylonitriles Exposure Toxicity Inspection Hazardous materials Standards Acrylic fibers Nitriles Cyanides Toxic substances Occupational safety and health Testimony Carcinogenesis Indoor air pollution CAS 107-13-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198724

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on Occupational Exposure to Acrylonitrile by R. Yodaiken, M.D., March 3, 1978.
PB87222865

Publication Date	1978
Page Count	34
Abstract	Testimony was presented concerning the establishment of an occupational exposure standard for acrylonitrile (107131) (AN) to which an estimated 125,000 workers were potentially exposed. Two year feeding and inhalation studies with animals indicated the chemical to be carcinogenic, producing tumors of the central nervous system (CNS), cerebral tumors, squamous cell neoplasms of the Zymbal gland, adenocarcinoma of the small intestine and large intestine, along with numerous benign tumors. Other findings included papillomata in the stomach, hemangioma of the kidney, fibroadenomas of the mammary gland, benign tumors of the uterus, and tumors of the ear canal. Teratogenicity studies indicated increased incidence of fetal malformation. Cases of AN as an allergen causing contact dermatitis and ulcers have been widely documented. It was recommended that drugs essential to the treatment of acute intoxication from AN be kept in the medical facility of all facilities using AN, and that employers institute a respiratory protection program in accordance with requirements.
Keywords	Environmental surveys Industrial medicine Acrylonitriles Exposure Toxicity Inspection Hazardous materials Standards Acrylic fibers Nitriles Cyanides Toxic substances Occupational safety and health Testimony Carcinogenesis Indoor air pollution CAS 107-13-1
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198724