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NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.

PB87222667

Publication Date	1986
Page Count	12
Abstract	The testimony reviewed the history of benzene (71432) exposure and the development of recommended exposure limits. Data were reviewed on pharmacokinetics, cytotoxicity, long- and short-term exposures, and skin absorption of benzene. Benzene or its metabolites have been shown to remain in the body for a long period of time following inhalation exposure. Studies in mice revealed exposure-related increases in the frequency of sister chromatid exchanges and micronuclei at all exposure concentrations. Some epidemiological standards relating to the benzene standard were cited. NIOSH recommended that the Permissible Exposure Limit for benzene be reduced to 0.1 ppm as an 8-hour time-weighted average, and that there be a limit on short-term exposures of 1.0ppm for any 15-minute period. These recommendations were made to protect against inhalation of benzene and did not relate to skin absorption. Reports indicated that significant benzene absorption can result among workers exposed to solvents containing about 0.5 percent benzene. It was recommended that steps be taken to eliminate this route of exposure. The use of pressure-demand supplied air respirators with an auxiliary self-contained breathing apparatus or a pressure-demand apparatus was recommended.
Keywords	Industrial medicine Benzene Exposure Toxicity Hazardous materials Standards Limits Organic solvents Drugs Dyes Paints Respiration Absorption Air pollution Testimony Toxic substances Occupational safety and health CAS 71-43-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198724

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.

NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.
PB87222667

Publication Date	1986
Page Count	12
Abstract	The testimony reviewed the history of benzene (71432) exposure and the development of recommended exposure limits. Data were reviewed on pharmacokinetics, cytotoxicity, long- and short-term exposures, and skin absorption of benzene. Benzene or its metabolites have been shown to remain in the body for a long period of time following inhalation exposure. Studies in mice revealed exposure-related increases in the frequency of sister chromatid exchanges and micronuclei at all exposure concentrations. Some epidemiological standards relating to the benzene standard were cited. NIOSH recommended that the Permissible Exposure Limit for benzene be reduced to 0.1 ppm as an 8-hour time-weighted average, and that there be a limit on short-term exposures of 1.0ppm for any 15-minute period. These recommendations were made to protect against inhalation of benzene and did not relate to skin absorption. Reports indicated that significant benzene absorption can result among workers exposed to solvents containing about 0.5 percent benzene. It was recommended that steps be taken to eliminate this route of exposure. The use of pressure-demand supplied air respirators with an auxiliary self-contained breathing apparatus or a pressure-demand apparatus was recommended.
Keywords	Industrial medicine Benzene Exposure Toxicity Hazardous materials Standards Limits Organic solvents Drugs Dyes Paints Respiration Absorption Air pollution Testimony Toxic substances Occupational safety and health CAS 71-43-2
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198724