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NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.


PB87222667

Publication Date 1986
Page Count 12
Abstract The testimony reviewed the history of benzene (71432) exposure and the development of recommended exposure limits. Data were reviewed on pharmacokinetics, cytotoxicity, long- and short-term exposures, and skin absorption of benzene. Benzene or its metabolites have been shown to remain in the body for a long period of time following inhalation exposure. Studies in mice revealed exposure-related increases in the frequency of sister chromatid exchanges and micronuclei at all exposure concentrations. Some epidemiological standards relating to the benzene standard were cited. NIOSH recommended that the Permissible Exposure Limit for benzene be reduced to 0.1 ppm as an 8-hour time-weighted average, and that there be a limit on short-term exposures of 1.0ppm for any 15-minute period. These recommendations were made to protect against inhalation of benzene and did not relate to skin absorption. Reports indicated that significant benzene absorption can result among workers exposed to solvents containing about 0.5 percent benzene. It was recommended that steps be taken to eliminate this route of exposure. The use of pressure-demand supplied air respirators with an auxiliary self-contained breathing apparatus or a pressure-demand apparatus was recommended.
Keywords
  • Industrial medicine
  • Benzene
  • Exposure
  • Toxicity
  • Hazardous materials
  • Standards
  • Limits
  • Organic solvents
  • Drugs
  • Dyes
  • Paints
  • Respiration
  • Absorption
  • Air pollution
  • Testimony
  • Toxic substances
  • Occupational safety and health
  • CAS 71-43-2
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
Corporate Authors National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198724
NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.
NIOSH (National Institute for Occupational Safety and Health) Testimony to DOL (Department of Labor) on OSHA (Occupational Safety and Health Administration) Proposed Rule for Occupational Exposure to Benzene by R. Lemen, March 20, 1986.
PB87222667

  • Industrial medicine
  • Benzene
  • Exposure
  • Toxicity
  • Hazardous materials
  • Standards
  • Limits
  • Organic solvents
  • Drugs
  • Dyes
  • Paints
  • Respiration
  • Absorption
  • Air pollution
  • Testimony
  • Toxic substances
  • Occupational safety and health
  • CAS 71-43-2
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
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