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The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

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Impact of Coal Dust in Gastric Cancer and Defense Mechanisms.

PB87222162

Publication Date	1986
Page Count	16
Abstract	In efforts to further define the role of exposure to coal dust in subsequent development of gastric cancer, several studies have been performed and were highlighted in the report. Studies on the mutagenicity of different ranks of coal dust were conducted using the Ames Salmonella mutagenicity assay system. High mutagenic activity was found when extracts of bituminous, sub bituminous, and lignite coal dust were reacted with nitrite, a chemical found in the stomach, under acidic conditions. Studies on the effect of coal dust and its extracts on the interferon system indicated that nitrosated coal dust extracts at acidic conditions contain substances which are highly mutagenic and inhibitory for interferon induction. Virus infection studies were performed with the cytochrome-P-450 enzyme in efforts to understand the relationship between xenobiotic metabolism and antiviral activity in mice exposed to coal dust.
Keywords	Coal dust Neoplasms Gastrointestinal diseases Mutagenicity Lignite Bituminous coal Tests Coal mining Carcinogens Occupational safety and health
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57E - Clinical Medicine 44G - Environmental & Occupational Factors 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198723

Impact of Coal Dust in Gastric Cancer and Defense Mechanisms.

Impact of Coal Dust in Gastric Cancer and Defense Mechanisms.
PB87222162

Publication Date	1986
Page Count	16
Abstract	In efforts to further define the role of exposure to coal dust in subsequent development of gastric cancer, several studies have been performed and were highlighted in the report. Studies on the mutagenicity of different ranks of coal dust were conducted using the Ames Salmonella mutagenicity assay system. High mutagenic activity was found when extracts of bituminous, sub bituminous, and lignite coal dust were reacted with nitrite, a chemical found in the stomach, under acidic conditions. Studies on the effect of coal dust and its extracts on the interferon system indicated that nitrosated coal dust extracts at acidic conditions contain substances which are highly mutagenic and inhibitory for interferon induction. Virus infection studies were performed with the cytochrome-P-450 enzyme in efforts to understand the relationship between xenobiotic metabolism and antiviral activity in mice exposed to coal dust.
Keywords	Coal dust Neoplasms Gastrointestinal diseases Mutagenicity Lignite Bituminous coal Tests Coal mining Carcinogens Occupational safety and health
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57E - Clinical Medicine 44G - Environmental & Occupational Factors 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198723