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Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).


PB87210878

Publication Date 1973
Personal Author Lassiter, D. V.
Page Count 15
Abstract The toxic hazards of exposure to alpha-naphthylamine (1-NA) are discussed. Its use in the manufacture of azo dyes and in the rubber industry is noted, and the phenomenon of aniline cancer is described. The concentration of beta-naphthylamine (2-NA) found in industrial 1-NA is discussed. The results of 1-NA carcinogenicity tests in rabbits, rats, dogs, mice, and hamsters are summarized, along with species differences in 1-NA metabolism. The relative carcinogenicity of N-hydroxylated derivatives of naphthylamines is reviewed, including tumor induction rates for 1-naphthylhydroxylamine and 2-naphthylhydroxylamine. The carcinogenic potentials of the 1 nitroso and 2 nitroso compounds of 1-NA and 2-NA are compared. Findings from several epidemiological surveys of workers exposed to 1-NA are discussed, including occurrences of sessile papillomas and bladder tumors in relation to duration and degree of exposure. The possible interaction between 1-NA and 2-NA in inducing bladder tumors is considered. The mutagenicity of the N-hydroxylated derivatives is described along with the relationship between carcinogenicity and mutagenicity.
Keywords
  • Industrial medicine
  • Environmental surveys
  • Carcinogens
  • Laboratory animals
  • Rubber industry
  • Dyes
  • Exposure
  • Toxic substances
  • Occupational safety and health
  • Naphthylamine/alpha
  • Naphthylamine/beta
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 41I - Job Environment
Corporate Authors National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
NTIS Issue Number 198721
Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).
Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).
PB87210878

  • Industrial medicine
  • Environmental surveys
  • Carcinogens
  • Laboratory animals
  • Rubber industry
  • Dyes
  • Exposure
  • Toxic substances
  • Occupational safety and health
  • Naphthylamine/alpha
  • Naphthylamine/beta
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 41I - Job Environment
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