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Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).

PB87210878

Publication Date	1973
Personal Author	Lassiter, D. V.
Page Count	15
Abstract	The toxic hazards of exposure to alpha-naphthylamine (1-NA) are discussed. Its use in the manufacture of azo dyes and in the rubber industry is noted, and the phenomenon of aniline cancer is described. The concentration of beta-naphthylamine (2-NA) found in industrial 1-NA is discussed. The results of 1-NA carcinogenicity tests in rabbits, rats, dogs, mice, and hamsters are summarized, along with species differences in 1-NA metabolism. The relative carcinogenicity of N-hydroxylated derivatives of naphthylamines is reviewed, including tumor induction rates for 1-naphthylhydroxylamine and 2-naphthylhydroxylamine. The carcinogenic potentials of the 1 nitroso and 2 nitroso compounds of 1-NA and 2-NA are compared. Findings from several epidemiological surveys of workers exposed to 1-NA are discussed, including occurrences of sessile papillomas and bladder tumors in relation to duration and degree of exposure. The possible interaction between 1-NA and 2-NA in inducing bladder tumors is considered. The mutagenicity of the N-hydroxylated derivatives is described along with the relationship between carcinogenicity and mutagenicity.
Keywords	Industrial medicine Environmental surveys Carcinogens Laboratory animals Rubber industry Dyes Exposure Toxic substances Occupational safety and health Naphthylamine/alpha Naphthylamine/beta
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 41I - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198721

Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).

Hazard Review of Alpha-Naphthylamine (1-NA) (1-Naphthylamine).
PB87210878

Publication Date	1973
Personal Author	Lassiter, D. V.
Page Count	15
Abstract	The toxic hazards of exposure to alpha-naphthylamine (1-NA) are discussed. Its use in the manufacture of azo dyes and in the rubber industry is noted, and the phenomenon of aniline cancer is described. The concentration of beta-naphthylamine (2-NA) found in industrial 1-NA is discussed. The results of 1-NA carcinogenicity tests in rabbits, rats, dogs, mice, and hamsters are summarized, along with species differences in 1-NA metabolism. The relative carcinogenicity of N-hydroxylated derivatives of naphthylamines is reviewed, including tumor induction rates for 1-naphthylhydroxylamine and 2-naphthylhydroxylamine. The carcinogenic potentials of the 1 nitroso and 2 nitroso compounds of 1-NA and 2-NA are compared. Findings from several epidemiological surveys of workers exposed to 1-NA are discussed, including occurrences of sessile papillomas and bladder tumors in relation to duration and degree of exposure. The possible interaction between 1-NA and 2-NA in inducing bladder tumors is considered. The mutagenicity of the N-hydroxylated derivatives is described along with the relationship between carcinogenicity and mutagenicity.
Keywords	Industrial medicine Environmental surveys Carcinogens Laboratory animals Rubber industry Dyes Exposure Toxic substances Occupational safety and health Naphthylamine/alpha Naphthylamine/beta
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 41I - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198721