National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Hazard Review of Beta-Naphthylamine (2-NA).

PB87210852

Publication Date	1973
Personal Author	Lassiter, D. V.
Page Count	24
Abstract	The hazards of occupational exposure to beta-naphthylamine are reviewed. The epidemiological pitfalls of determining carcinogenicity of the dye are outlined. These are: worker exposure to more than one suspect compound, complicated by shifting of workers between departments; different degrees of exposure hazard between processes; unsuspected impurities in trace amounts that are possibly more harmful than the parent compound; and differences in composition of dyes and production methods in different factories that complicate statistical comparisons. Animal experiments are cited in which dogs given subcutaneous injections or fed the dye developed bladder tumors. Bladder papillomas, hepatomas, bronchogenic carcinomas, and lung carcinomas produced in Wistar-rats are noted. Proof of carcinogenicity of the dye in mice, monkeys, and hamsters is also presented. Fifteen metabolites identified for beta-naphthylamine are listed. An epidemiological study is described in which 109 of 376 workers exposed to beta-naphthylamine and other aromatic amines in a dye factory had bladder malignancies.
Keywords	Environmental surveys Industrial medicine Exposure Carcinogens Amine/naphthy Toxic substances Occupational safety and health Biostatistics
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 41I - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198721

Hazard Review of Beta-Naphthylamine (2-NA).

Hazard Review of Beta-Naphthylamine (2-NA).
PB87210852

Publication Date	1973
Personal Author	Lassiter, D. V.
Page Count	24
Abstract	The hazards of occupational exposure to beta-naphthylamine are reviewed. The epidemiological pitfalls of determining carcinogenicity of the dye are outlined. These are: worker exposure to more than one suspect compound, complicated by shifting of workers between departments; different degrees of exposure hazard between processes; unsuspected impurities in trace amounts that are possibly more harmful than the parent compound; and differences in composition of dyes and production methods in different factories that complicate statistical comparisons. Animal experiments are cited in which dogs given subcutaneous injections or fed the dye developed bladder tumors. Bladder papillomas, hepatomas, bronchogenic carcinomas, and lung carcinomas produced in Wistar-rats are noted. Proof of carcinogenicity of the dye in mice, monkeys, and hamsters is also presented. Fifteen metabolites identified for beta-naphthylamine are listed. An epidemiological study is described in which 109 of 376 workers exposed to beta-naphthylamine and other aromatic amines in a dye factory had bladder malignancies.
Keywords	Environmental surveys Industrial medicine Exposure Carcinogens Amine/naphthy Toxic substances Occupational safety and health Biostatistics
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 41I - Job Environment
Corporate Authors	National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198721