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Hazard Review of Bis(Chloromethyl)Ether (BCME).


PB87210779

Publication Date 1973
Personal Author Lassiter, D. V.
Page Count 17
Abstract The toxic hazards of bis(chloromethyl)ether (BCME) are discussed. The findings of a variety of studies on BCME carcinogenicity in laboratory animals are summarized, including skin painting tests in Swiss-mice, injection tests in rats, subcutaneous injection tests in Swiss-mice, inhalation exposure tests in mice and Sprague-Dawley-rats. Occurrences of fibrosarcomas, fibromas, and lung adenomas in these animals are discussed. The results of a NIOSH survey of bronchial damage and lung cancer incidence among workers exposed to BCME at an anion exchange resin production factory are reviewed, including an increased incidence of abnormal sputum cytology and of lung cancer, particularly undifferentiated oat cell carcinoma. An increased incidence of lung cancer among workers exposed to chloromethyl-methyl-ether is discussed with respect to the probable concomitant exposure to BCME. Lung cancer deaths are also discussed among 8 of 68 workers from a facility where BCME exposures occurred. The formation of BCME from the reaction of hydrogen-chloride with formaldehyde is described.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Chlorine organic compounds
  • Carcinogens
  • Exposure
  • Respiratory diseases
  • Toxic substances
  • Occupational safety and health
  • Ether/bis(chloromethyl)
  • Ether/chloromethyl-methyl
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 41I - Job Environment
Corporate Authors National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type Technical Report
NTIS Issue Number 198721
Hazard Review of Bis(Chloromethyl)Ether (BCME).
Hazard Review of Bis(Chloromethyl)Ether (BCME).
PB87210779

  • Environmental surveys
  • Industrial medicine
  • Chlorine organic compounds
  • Carcinogens
  • Exposure
  • Respiratory diseases
  • Toxic substances
  • Occupational safety and health
  • Ether/bis(chloromethyl)
  • Ether/chloromethyl-methyl
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 41I - Job Environment
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