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Oncogenic Potential of Vinyl Bromide during Chronic Inhalation Exposure. Twelve Month Interim Report - Project Number 7511-253. Volume 1.

PB87207460

Publication Date	1977
Page Count	104
Abstract	Pathologic lesions produced by chronic inhalation of vinyl-bromide (593602) was investigated in rats. All tissues from rats exposed to 0, 9.7, 52, 247 and 1235 parts per million (ppm) vinyl-bromide for 12 and 18 months were examined histologically. Liver angiosarcomas were also found in the lung, spleen, nasal cavity, and mesentery. Incidence of metastasis to the lung was high. Hepatic angiosarcoma comprised of large blood filled cysts surrounded by proliferating neoplastic endothelial cells. Zymbal gland neoplasms occurred in the 1235 ppm group in both sexes and in males of 247 ppm group. It was either a squamous cell carcinoma or papilloma. Proliferative and neoplastic hepatocytic lesions were found in both sexes in all dose groups but a dose related pattern was not evident. The hepatic neoplasms were either neoplastic nodules or hepatocellular carcinomas. The neoplastic nodules were characterized by proliferation of differential neoplastic hepatocytes which formed discrete nodules while the carcinomas showed proliferation of poorly differentiated neoplastic hepatocytes invading the liver parenchyma.
Keywords	Toxicology Bioassay Rats Laboratory animals Inhalation Vinyl bromide Air pollution effects(Animals) CAS 593-60-2 Oncogenesis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology 68A - Air Pollution & Control
Corporate Authors	Huntingdon Research Center, New City, NY.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also Volume 2, PB87-207478. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198722

Oncogenic Potential of Vinyl Bromide during Chronic Inhalation Exposure. Twelve Month Interim Report - Project Number 7511-253. Volume 1.

Oncogenic Potential of Vinyl Bromide during Chronic Inhalation Exposure. Twelve Month Interim Report - Project Number 7511-253. Volume 1.
PB87207460

Publication Date	1977
Page Count	104
Abstract	Pathologic lesions produced by chronic inhalation of vinyl-bromide (593602) was investigated in rats. All tissues from rats exposed to 0, 9.7, 52, 247 and 1235 parts per million (ppm) vinyl-bromide for 12 and 18 months were examined histologically. Liver angiosarcomas were also found in the lung, spleen, nasal cavity, and mesentery. Incidence of metastasis to the lung was high. Hepatic angiosarcoma comprised of large blood filled cysts surrounded by proliferating neoplastic endothelial cells. Zymbal gland neoplasms occurred in the 1235 ppm group in both sexes and in males of 247 ppm group. It was either a squamous cell carcinoma or papilloma. Proliferative and neoplastic hepatocytic lesions were found in both sexes in all dose groups but a dose related pattern was not evident. The hepatic neoplasms were either neoplastic nodules or hepatocellular carcinomas. The neoplastic nodules were characterized by proliferation of differential neoplastic hepatocytes which formed discrete nodules while the carcinomas showed proliferation of poorly differentiated neoplastic hepatocytes invading the liver parenchyma.
Keywords	Toxicology Bioassay Rats Laboratory animals Inhalation Vinyl bromide Air pollution effects(Animals) CAS 593-60-2 Oncogenesis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology 68A - Air Pollution & Control
Corporate Authors	Huntingdon Research Center, New City, NY.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also Volume 2, PB87-207478. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198722