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Information Profiles on Potential Occupational Hazards: Benzoin.

PB87174629

Publication Date	1981
Page Count	19
Abstract	Information on potential occupational hazards from exposure to benzoin (119539) was reviewed. Topics discussed included chemical and physical properties, production, uses, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. The annual production of benzoin is approximately 90,000 pounds per year with an historical growth rate of about 6 percent per year. In carcinogenesis studies, the incidence of lymphomas and leukemia in dosed male rats increased with dose level, but not significantly. Mice demonstrated a significant increase in the incidence of lymphomas and leukemias at low dose levels. Bioassays have indicated that benzoin is not carcinogenic to male or female F344-rats or B6C3F1-mice. No evidence of mutagenicity, teratogenicity, or reproductive effects was found in animal studies. Allergic contact dermatitis has been reported in humans.
Keywords	Environmental surveys Industrial medicine Drug industry Benzoin Chemical industry Exposure Toxicity Inspection Hazardous materials Air pollution Toxic substances Occupational safety and health Indoor air pollution
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198715
Contract Number	PHS-NIOSH-210-79-0030

Information Profiles on Potential Occupational Hazards: Benzoin.

Information Profiles on Potential Occupational Hazards: Benzoin.
PB87174629

Publication Date	1981
Page Count	19
Abstract	Information on potential occupational hazards from exposure to benzoin (119539) was reviewed. Topics discussed included chemical and physical properties, production, uses, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. The annual production of benzoin is approximately 90,000 pounds per year with an historical growth rate of about 6 percent per year. In carcinogenesis studies, the incidence of lymphomas and leukemia in dosed male rats increased with dose level, but not significantly. Mice demonstrated a significant increase in the incidence of lymphomas and leukemias at low dose levels. Bioassays have indicated that benzoin is not carcinogenic to male or female F344-rats or B6C3F1-mice. No evidence of mutagenicity, teratogenicity, or reproductive effects was found in animal studies. Allergic contact dermatitis has been reported in humans.
Keywords	Environmental surveys Industrial medicine Drug industry Benzoin Chemical industry Exposure Toxicity Inspection Hazardous materials Air pollution Toxic substances Occupational safety and health Indoor air pollution
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198715
Contract Number	PHS-NIOSH-210-79-0030