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Information Profiles on Potential Occupational Hazards: Adipic Acid. Second Draft.

PB87174322

Publication Date	1981
Page Count	28
Abstract	Information on potential occupational hazards from exposure to adipic-acid (124049) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Administration of adipic acid to experimental animals has produced patchy livers, irritation of organs directly exposed, hemorrhagic lungs and symptoms of acidosis. Subchronic exposures in rats produced symptoms of toxicity including depression, dyspnea, ataxia, and convulsions. No significant evidence for carcinogenicity has been reported nor has there been any finding of mutagenicity or teratogenicity or any reproductive effects. No evidence of toxicity was found on oral administration of 100mg/kg adipic-acid per day to human subjects.
Keywords	Adipic acid Industrial medicine Hazardous materials Toxicity Nylon 66 Nylon fibers Polyamide resins Polyurethane resins Plasticizers Food additives Exposure Acidosis Insecticides Adhesives Textile industry Tanning materials Leather Occupational safety and health Toxic substances
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198715
Contract Number	PHS-NIOSH-210-79-0030

Information Profiles on Potential Occupational Hazards: Adipic Acid. Second Draft.

Information Profiles on Potential Occupational Hazards: Adipic Acid. Second Draft.
PB87174322

Publication Date	1981
Page Count	28
Abstract	Information on potential occupational hazards from exposure to adipic-acid (124049) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Administration of adipic acid to experimental animals has produced patchy livers, irritation of organs directly exposed, hemorrhagic lungs and symptoms of acidosis. Subchronic exposures in rats produced symptoms of toxicity including depression, dyspnea, ataxia, and convulsions. No significant evidence for carcinogenicity has been reported nor has there been any finding of mutagenicity or teratogenicity or any reproductive effects. No evidence of toxicity was found on oral administration of 100mg/kg adipic-acid per day to human subjects.
Keywords	Adipic acid Industrial medicine Hazardous materials Toxicity Nylon 66 Nylon fibers Polyamide resins Polyurethane resins Plasticizers Food additives Exposure Acidosis Insecticides Adhesives Textile industry Tanning materials Leather Occupational safety and health Toxic substances
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.; National Inst. for Occupational Safety and Health, Rockville, MD.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Rockville, MD.
Document Type	Technical Report
NTIS Issue Number	198715
Contract Number	PHS-NIOSH-210-79-0030