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Chronic Inhalation Toxicity Study of 1,2-Dichloroethane (EDC) in Rats Treated with Disulfiram or Ethanol. Part 1. Toxicology and Pathology.

PB87165056

Publication Date	1985
Personal Author	Cholakis, J. M.; Steele, D. H.; Peterson, S. D.; Hagensen, J. H.; Liu, G. K.
Page Count	400
Abstract	Sprague-Dawley-rats were used to study the effects of inhaled 1,2-dichloroethane (107062) (EDC) in the presence and absence of disulfiram (97778) in the diet, and with or without ethanol (64175) in the drinking water. Rats were exposed to EDC at 50 parts per million for 7 hours per day, 5 days per week for 24 months. All animals receiving disulfiram showed lower body weight gains, but demonstrated no other changes regarding toxicity, survival or food intake. An increased incidence of liver masses was noted in male and female rats receiving EDC and disulfiram. This finding is in agreement with other findings concerning the synergistic effects of haloethanes and disulfiram. The pharmacological agent greatly enhanced the carcinogenicity of the carcinogen. The high incidence of intrahepatic bile duct cholangiomas in both male and female rats and neoplastic nodules in male rats indicate that the combined EDC/disulfiram treatment must be considered carcinogenic to the liver. Male rats also showed significantly increased interstitial cell tumors of the testes and fibromas of the subcutis. Female rats demonstrated increased incidence of adenocarcinomas of the mammary gland. Kidney lesions were more frequent in the male EDC treatment group.
Keywords	Toxicology Drugs Laboratory animals Pathology Solvents Chlorine organic compounds Dosage Bioassay Rats Ethane/dichloro Disulfiram Ethanol CAS 107-06-2 CAS 97-77-8 CAS 64-17-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also Part 2, PB87-165064. Portions of this document are not fully legible. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198713
Contract Number	PHS-NIOSH-200-82-2508

Chronic Inhalation Toxicity Study of 1,2-Dichloroethane (EDC) in Rats Treated with Disulfiram or Ethanol. Part 1. Toxicology and Pathology.

Chronic Inhalation Toxicity Study of 1,2-Dichloroethane (EDC) in Rats Treated with Disulfiram or Ethanol. Part 1. Toxicology and Pathology.
PB87165056

Publication Date	1985
Personal Author	Cholakis, J. M.; Steele, D. H.; Peterson, S. D.; Hagensen, J. H.; Liu, G. K.
Page Count	400
Abstract	Sprague-Dawley-rats were used to study the effects of inhaled 1,2-dichloroethane (107062) (EDC) in the presence and absence of disulfiram (97778) in the diet, and with or without ethanol (64175) in the drinking water. Rats were exposed to EDC at 50 parts per million for 7 hours per day, 5 days per week for 24 months. All animals receiving disulfiram showed lower body weight gains, but demonstrated no other changes regarding toxicity, survival or food intake. An increased incidence of liver masses was noted in male and female rats receiving EDC and disulfiram. This finding is in agreement with other findings concerning the synergistic effects of haloethanes and disulfiram. The pharmacological agent greatly enhanced the carcinogenicity of the carcinogen. The high incidence of intrahepatic bile duct cholangiomas in both male and female rats and neoplastic nodules in male rats indicate that the combined EDC/disulfiram treatment must be considered carcinogenic to the liver. Male rats also showed significantly increased interstitial cell tumors of the testes and fibromas of the subcutis. Female rats demonstrated increased incidence of adenocarcinomas of the mammary gland. Kidney lesions were more frequent in the male EDC treatment group.
Keywords	Toxicology Drugs Laboratory animals Pathology Solvents Chlorine organic compounds Dosage Bioassay Rats Ethane/dichloro Disulfiram Ethanol CAS 107-06-2 CAS 97-77-8 CAS 64-17-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57Q - Pharmacology & Pharmacological Chemistry
Corporate Authors	Midwest Research Inst., Kansas City, MO.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also Part 2, PB87-165064. Portions of this document are not fully legible. Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198713
Contract Number	PHS-NIOSH-200-82-2508