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Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.

PB86103207

Publication Date	1985
Personal Author	Reel, J. R.; George, J. D.; Lawton, A. D.; Myers, C. B.
Page Count	348
Abstract	Bisphenol A (BPA; 98% pure) was evaluated in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. In the present study, Task 1 (dose-range finding) was performed to aid in the selection of dose levels for Task 2 (continuous breeding). Eight male and eight female CD-1 mice (8 weeks of age) per dose group were given 0.0, 0.31, 0.62, 1.25, 2.5 and 5.0% BPA in their feed (NIH-07) for 14 days. Analysis of the Task 1 feed formulations indicated that they ranged from 93 to 102% of the desired BPA concentrations. No clinical signs of toxicity were observed in either male or female mice in the 0.0, 0.31, 0.62, or 1.25% BPA dose groups.
Keywords	Toxicology Reproduction(Biology) Fertility Assessments Mice Laboratory animals Exposure Resins Dosage Bisphenol A Silastic Histopathology Implantation
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also PB84-155308, and PB86-103215. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept. 14 Mar-11 Oct 84.
NTIS Issue Number	198601
Contract Number	N01-ES-2-5014

Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.

Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.
PB86103207

Publication Date	1985
Personal Author	Reel, J. R.; George, J. D.; Lawton, A. D.; Myers, C. B.
Page Count	348
Abstract	Bisphenol A (BPA; 98% pure) was evaluated in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. In the present study, Task 1 (dose-range finding) was performed to aid in the selection of dose levels for Task 2 (continuous breeding). Eight male and eight female CD-1 mice (8 weeks of age) per dose group were given 0.0, 0.31, 0.62, 1.25, 2.5 and 5.0% BPA in their feed (NIH-07) for 14 days. Analysis of the Task 1 feed formulations indicated that they ranged from 93 to 102% of the desired BPA concentrations. No clinical signs of toxicity were observed in either male or female mice in the 0.0, 0.31, 0.62, or 1.25% BPA dose groups.
Keywords	Toxicology Reproduction(Biology) Fertility Assessments Mice Laboratory animals Exposure Resins Dosage Bisphenol A Silastic Histopathology Implantation
Source Agency	National Institute of Environmental Health Sciences
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes	See also PB84-155308, and PB86-103215. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type	Technical Report
Title Note	Final rept. 14 Mar-11 Oct 84.
NTIS Issue Number	198601
Contract Number	N01-ES-2-5014