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Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.


PB86103207

Publication Date 1985
Personal Author Reel, J. R.; George, J. D.; Lawton, A. D.; Myers, C. B.
Page Count 348
Abstract Bisphenol A (BPA; 98% pure) was evaluated in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. In the present study, Task 1 (dose-range finding) was performed to aid in the selection of dose levels for Task 2 (continuous breeding). Eight male and eight female CD-1 mice (8 weeks of age) per dose group were given 0.0, 0.31, 0.62, 1.25, 2.5 and 5.0% BPA in their feed (NIH-07) for 14 days. Analysis of the Task 1 feed formulations indicated that they ranged from 93 to 102% of the desired BPA concentrations. No clinical signs of toxicity were observed in either male or female mice in the 0.0, 0.31, 0.62, or 1.25% BPA dose groups.
Keywords
  • Toxicology
  • Reproduction(Biology)
  • Fertility
  • Assessments
  • Mice
  • Laboratory animals
  • Exposure
  • Resins
  • Dosage
  • Bisphenol A
  • Silastic
  • Histopathology
  • Implantation
Source Agency
  • National Institute of Environmental Health Sciences
NTIS Subject Category
  • 57Y - Toxicology
  • 57O - Pathology
Corporate Authors Research Triangle Inst., Research Triangle Park, NC.; National Toxicology Program, Research Triangle Park, NC.
Supplemental Notes See also PB84-155308, and PB86-103215. Sponsored by National Toxicology Program, Research Triangle Park, NC.
Document Type Technical Report
Title Note Final rept. 14 Mar-11 Oct 84.
NTIS Issue Number 198601
Contract Number
  • N01-ES-2-5014
Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.
Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed.
PB86103207

  • Toxicology
  • Reproduction(Biology)
  • Fertility
  • Assessments
  • Mice
  • Laboratory animals
  • Exposure
  • Resins
  • Dosage
  • Bisphenol A
  • Silastic
  • Histopathology
  • Implantation
  • National Institute of Environmental Health Sciences
  • 57Y - Toxicology
  • 57O - Pathology
  • N01-ES-2-5014
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