National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.

PB85221398

Publication Date	1979
Personal Author	Nony, C. R.
Page Count	86
Abstract	The metabolism of azo dyes to potentially carcinogenic aromatic amines was studied in hamsters. Male Syrian-golden-hamsters were administered 100 milligrams per kilogram Direct-Black-38 (1937377) or Pigment-Yellow-12 (6358856) intragastrically. Urine samples were collected at intervals for up to 7 days and analyzed for metabolites. Urine from hamsters given Direct-Black-38 contained 206 micrograms (microg) monoacetylbenzidine (3366618), 6.74 microg diacetylbenzidine (30773718), 2.57 microg 4-aminobiphenyl (92671), 3.33 microg benzidine (92875), and 103 microg alkaline hydrolyzable conjugates of benzidine. The author suggests that Pigment-Yellow-12 passes through the gastrointestinal tract of hamsters unchanged. Workers exposed to Direct-Black-38 could be at risk of developing bladder cancer.
Keywords	Amines Industrial medicine Environmental surveys Azo dyes Gas analysis Carcinogens Metabolism Mutagens Exposure Chemical analysis Gas chromatography Aromatic polycyclic hydrocarbons Urine Sampling Benzidines Risk Laboratory animals Direct Black 38 Pigment yellow 12 Benzidine/acetyl Benzidine/diacetyl Biphenyl/amino Benzidine CAS 1937-37-7 CAS 6358-85-6 CAS 3366-61-8 CAS 30773-71-8 CAS 92-67-1 CAS 92-87-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41E - Manufacturing, Planning, Processing & Control 99A - Analytical Chemistry
Corporate Authors	National Center for Toxicological Research, Jefferson, AR.; Food and Drug Administration, Washington, DC.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198522
Contract Number	FDA-224-78-0004

Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.

Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.
PB85221398

Publication Date	1979
Personal Author	Nony, C. R.
Page Count	86
Abstract	The metabolism of azo dyes to potentially carcinogenic aromatic amines was studied in hamsters. Male Syrian-golden-hamsters were administered 100 milligrams per kilogram Direct-Black-38 (1937377) or Pigment-Yellow-12 (6358856) intragastrically. Urine samples were collected at intervals for up to 7 days and analyzed for metabolites. Urine from hamsters given Direct-Black-38 contained 206 micrograms (microg) monoacetylbenzidine (3366618), 6.74 microg diacetylbenzidine (30773718), 2.57 microg 4-aminobiphenyl (92671), 3.33 microg benzidine (92875), and 103 microg alkaline hydrolyzable conjugates of benzidine. The author suggests that Pigment-Yellow-12 passes through the gastrointestinal tract of hamsters unchanged. Workers exposed to Direct-Black-38 could be at risk of developing bladder cancer.
Keywords	Amines Industrial medicine Environmental surveys Azo dyes Gas analysis Carcinogens Metabolism Mutagens Exposure Chemical analysis Gas chromatography Aromatic polycyclic hydrocarbons Urine Sampling Benzidines Risk Laboratory animals Direct Black 38 Pigment yellow 12 Benzidine/acetyl Benzidine/diacetyl Biphenyl/amino Benzidine CAS 1937-37-7 CAS 6358-85-6 CAS 3366-61-8 CAS 30773-71-8 CAS 92-67-1 CAS 92-87-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	68G - Environmental Health & Safety 57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41E - Manufacturing, Planning, Processing & Control 99A - Analytical Chemistry
Corporate Authors	National Center for Toxicological Research, Jefferson, AR.; Food and Drug Administration, Washington, DC.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198522
Contract Number	FDA-224-78-0004