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Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.


PB85221398

Publication Date 1979
Personal Author Nony, C. R.
Page Count 86
Abstract The metabolism of azo dyes to potentially carcinogenic aromatic amines was studied in hamsters. Male Syrian-golden-hamsters were administered 100 milligrams per kilogram Direct-Black-38 (1937377) or Pigment-Yellow-12 (6358856) intragastrically. Urine samples were collected at intervals for up to 7 days and analyzed for metabolites. Urine from hamsters given Direct-Black-38 contained 206 micrograms (microg) monoacetylbenzidine (3366618), 6.74 microg diacetylbenzidine (30773718), 2.57 microg 4-aminobiphenyl (92671), 3.33 microg benzidine (92875), and 103 microg alkaline hydrolyzable conjugates of benzidine. The author suggests that Pigment-Yellow-12 passes through the gastrointestinal tract of hamsters unchanged. Workers exposed to Direct-Black-38 could be at risk of developing bladder cancer.
Keywords
  • Amines
  • Industrial medicine
  • Environmental surveys
  • Azo dyes
  • Gas analysis
  • Carcinogens
  • Metabolism
  • Mutagens
  • Exposure
  • Chemical analysis
  • Gas chromatography
  • Aromatic polycyclic hydrocarbons
  • Urine
  • Sampling
  • Benzidines
  • Risk
  • Laboratory animals
  • Direct Black 38
  • Pigment yellow 12
  • Benzidine/acetyl
  • Benzidine/diacetyl
  • Biphenyl/amino
  • Benzidine
  • CAS 1937-37-7
  • CAS 6358-85-6
  • CAS 3366-61-8
  • CAS 30773-71-8
  • CAS 92-67-1
  • CAS 92-87-5
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 68G - Environmental Health & Safety
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 41E - Manufacturing, Planning, Processing & Control
  • 99A - Analytical Chemistry
Corporate Authors National Center for Toxicological Research, Jefferson, AR.; Food and Drug Administration, Washington, DC.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes Sponsored by National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 198522
Contract Number
  • FDA-224-78-0004
Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.
Metabolism of Azo Dyes of Potentially Carcinogenic Aromatic Amines.
PB85221398

  • Amines
  • Industrial medicine
  • Environmental surveys
  • Azo dyes
  • Gas analysis
  • Carcinogens
  • Metabolism
  • Mutagens
  • Exposure
  • Chemical analysis
  • Gas chromatography
  • Aromatic polycyclic hydrocarbons
  • Urine
  • Sampling
  • Benzidines
  • Risk
  • Laboratory animals
  • Direct Black 38
  • Pigment yellow 12
  • Benzidine/acetyl
  • Benzidine/diacetyl
  • Biphenyl/amino
  • Benzidine
  • CAS 1937-37-7
  • CAS 6358-85-6
  • CAS 3366-61-8
  • CAS 30773-71-8
  • CAS 92-67-1
  • CAS 92-87-5
  • National Institute for Occupational Safety and Health
  • 68G - Environmental Health & Safety
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 41E - Manufacturing, Planning, Processing & Control
  • 99A - Analytical Chemistry
  • FDA-224-78-0004
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