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Screening of Priority Chemicals for Potential Reproductive Hazard. Hazleton Study Nos. 6125-101 through 6125-110.

PB85220143

Publication Date	1983
Page Count	166
Abstract	As the chemical burden to which human beings are exposed increases, there is a need to identify, evaluate, and regulate compounds harmful to the human population. An increase in the incidence of occupationally-related reproductive dysfunctions (e.g., damaged germ cells, infertility, impotence) has produced a heightened awareness of the need to screen selected industrial chemicals and to develop priorities for more detailed traditional reproductive hazard testing. The testing program was conducted to determine the effects of 15 chemicals on reproductive performance and to evaluate their fetotoxicity when administered orally to pregnant mice on Days 7 through 14 of gestation.
Keywords	Toxicology Reproduction(Biology) Chemical compounds Environmental surveys Industrial medicine Laboratory animals Experimental design Bioassay Exposure Mice Physical properties Hazardous materials Industrial wastes Chemical properties Chemical composition Stability Safety Storage Tables(Data) Pathology Toxic substances Occupational safety and health Phthalic acid/(dibutyl-ester) Phthalic acid/(diisodecyl-ester) Phenylene diamine/N-isopropyl-N-phenyl Phthalic acid/bis(ethylhexyl-ester) Hexanol/ethyl Phthalic acid/(dihexyl-ester) Probenecid Phthalic acid/(ethylhexyl-ester) Phthalic acid/(dioctyl-ester) Phosphonic acid/(dimethyl-ester)-methyl) Phosphoric acid/tris(chloroethyl-ester) Phenylalanine Cinnamaldehyde
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 99 - Chemistry 94D - Job Environment 41I - Job Environment
Corporate Authors	Hazleton Labs. America, Inc., Madison, WI. Chemical and BioMedical Sciences Div.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB83-257600.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198521
Contract Number	PHS-NIOSH-210-82-2542

Screening of Priority Chemicals for Potential Reproductive Hazard. Hazleton Study Nos. 6125-101 through 6125-110.

Screening of Priority Chemicals for Potential Reproductive Hazard. Hazleton Study Nos. 6125-101 through 6125-110.
PB85220143

Publication Date	1983
Page Count	166
Abstract	As the chemical burden to which human beings are exposed increases, there is a need to identify, evaluate, and regulate compounds harmful to the human population. An increase in the incidence of occupationally-related reproductive dysfunctions (e.g., damaged germ cells, infertility, impotence) has produced a heightened awareness of the need to screen selected industrial chemicals and to develop priorities for more detailed traditional reproductive hazard testing. The testing program was conducted to determine the effects of 15 chemicals on reproductive performance and to evaluate their fetotoxicity when administered orally to pregnant mice on Days 7 through 14 of gestation.
Keywords	Toxicology Reproduction(Biology) Chemical compounds Environmental surveys Industrial medicine Laboratory animals Experimental design Bioassay Exposure Mice Physical properties Hazardous materials Industrial wastes Chemical properties Chemical composition Stability Safety Storage Tables(Data) Pathology Toxic substances Occupational safety and health Phthalic acid/(dibutyl-ester) Phthalic acid/(diisodecyl-ester) Phenylene diamine/N-isopropyl-N-phenyl Phthalic acid/bis(ethylhexyl-ester) Hexanol/ethyl Phthalic acid/(dihexyl-ester) Probenecid Phthalic acid/(ethylhexyl-ester) Phthalic acid/(dioctyl-ester) Phosphonic acid/(dimethyl-ester)-methyl) Phosphoric acid/tris(chloroethyl-ester) Phenylalanine Cinnamaldehyde
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57U - Public Health & Industrial Medicine 68G - Environmental Health & Safety 99 - Chemistry 94D - Job Environment 41I - Job Environment
Corporate Authors	Hazleton Labs. America, Inc., Madison, WI. Chemical and BioMedical Sciences Div.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes	See also PB83-257600.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198521
Contract Number	PHS-NIOSH-210-82-2542