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Carcinogenic Potential of Condensed Pyrolysis Effluents from Iron Foundry Casting Operations. Volume 1.

PB85215176

Publication Date	1984
Personal Author	Shellenberger, T. E.; Garner, F. M.; Plankenhorn, L. J.
Page Count	104
Abstract	A carcinogenesis bioassay of condensed pyrolysis effluents from iron foundry casting operations using hamsters was conducted. Syrian-golden-hamsters were administered effluents from shell sand, green sand, furan (110009) or urethane (51796) casting molds intratracheally weekly for 18 weeks. Concentrations were 5 or 10 milligrams (mg) per 0.2 milliliter distilled water except for effluents from the urethane mold which were administered in amounts of 2.5 or 5.0mg. Positive controls were given 3.0mg benzo(a)pyrene (50328) plus 3.0mg ferric-oxide (1309371) or 3.0mg ferric-oxide. The animals were maintained until 98 percent mortality occurred or up to 103 weeks in the case of females or 117 weeks in the case of males. None of the effluents induced a significant carcinogenic response. Comparable numbers of respiratory tract tumors occurred in effluent treated and vehicle controls. Malignant lung tumors occurred with an incidence of 54 to 64 percent in the positive controls. Alveolar and bronchiolar cell hyperplasia was round in all effluent treated and control animals. Nonrespiratory tract tumors occurred sporadically in all treated and control animals. The authors conclude that foundry mold effluents are not carcinogenic in hamsters at the concentrations used. The doses may have been too low, however, to induce a carcinogenic response.
Keywords	Environmental surveys Industrial medicine Carcinogens Bioassay Foundries Iron and steel industry Casting Exposure Toxicity Inspection Hazardous materials Air pollution Dosage Sampling Molding materials Laboratory animals Furan Urethanes Iron oxides Toxic substances Occupational safety and health Indoor air pollution CAS 110-00-9 CAS 51-79-6 Benzo(a)pyrene) Shell sand Green sand CAS 1309-37-1 CAS 50-32-8
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41I - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB85-215184.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198521
Contract Number	PHS-NIOSH-210-78-0033

Carcinogenic Potential of Condensed Pyrolysis Effluents from Iron Foundry Casting Operations. Volume 1.

Carcinogenic Potential of Condensed Pyrolysis Effluents from Iron Foundry Casting Operations. Volume 1.
PB85215176

Publication Date	1984
Personal Author	Shellenberger, T. E.; Garner, F. M.; Plankenhorn, L. J.
Page Count	104
Abstract	A carcinogenesis bioassay of condensed pyrolysis effluents from iron foundry casting operations using hamsters was conducted. Syrian-golden-hamsters were administered effluents from shell sand, green sand, furan (110009) or urethane (51796) casting molds intratracheally weekly for 18 weeks. Concentrations were 5 or 10 milligrams (mg) per 0.2 milliliter distilled water except for effluents from the urethane mold which were administered in amounts of 2.5 or 5.0mg. Positive controls were given 3.0mg benzo(a)pyrene (50328) plus 3.0mg ferric-oxide (1309371) or 3.0mg ferric-oxide. The animals were maintained until 98 percent mortality occurred or up to 103 weeks in the case of females or 117 weeks in the case of males. None of the effluents induced a significant carcinogenic response. Comparable numbers of respiratory tract tumors occurred in effluent treated and vehicle controls. Malignant lung tumors occurred with an incidence of 54 to 64 percent in the positive controls. Alveolar and bronchiolar cell hyperplasia was round in all effluent treated and control animals. Nonrespiratory tract tumors occurred sporadically in all treated and control animals. The authors conclude that foundry mold effluents are not carcinogenic in hamsters at the concentrations used. The doses may have been too low, however, to induce a carcinogenic response.
Keywords	Environmental surveys Industrial medicine Carcinogens Bioassay Foundries Iron and steel industry Casting Exposure Toxicity Inspection Hazardous materials Air pollution Dosage Sampling Molding materials Laboratory animals Furan Urethanes Iron oxides Toxic substances Occupational safety and health Indoor air pollution CAS 110-00-9 CAS 51-79-6 Benzo(a)pyrene) Shell sand Green sand CAS 1309-37-1 CAS 50-32-8
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 41I - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB85-215184.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198521
Contract Number	PHS-NIOSH-210-78-0033