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Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.

PB84241991

Publication Date	1984
Page Count	430
Abstract	Data from a carcinogenicity study of foundry particulates, silica (14808607) and silica sand substitutes in hamsters are presented. Results indicated that silica sand and 10 silica sand substitutes were found not to be carcinogenic when administered by intratracheal instillation to male Syrian-Golden-hamsters. When given with benzo(a)pyrene (50328), the substances showed a definite cocarcinogenic effect in the hamster respiratory system. A tumor inventory and group and individual summaries of the histopathological findings of the study are provided. Organs and tissues examined for histopathological changes are listed. Tumors observed included squamous cell carcinomas, metastatic adenocarcinomas, polyps, cortical cell adenomas and reticular cell sarcomas. Mortality data is also provided.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Sands Mortality Air pollution Malignant neoplasms Laboratory animals Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB84-241983. Portions of this document are not fully legible.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.
PB84241991

Publication Date	1984
Page Count	430
Abstract	Data from a carcinogenicity study of foundry particulates, silica (14808607) and silica sand substitutes in hamsters are presented. Results indicated that silica sand and 10 silica sand substitutes were found not to be carcinogenic when administered by intratracheal instillation to male Syrian-Golden-hamsters. When given with benzo(a)pyrene (50328), the substances showed a definite cocarcinogenic effect in the hamster respiratory system. A tumor inventory and group and individual summaries of the histopathological findings of the study are provided. Organs and tissues examined for histopathological changes are listed. Tumors observed included squamous cell carcinomas, metastatic adenocarcinomas, polyps, cortical cell adenomas and reticular cell sarcomas. Mortality data is also provided.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Sands Mortality Air pollution Malignant neoplasms Laboratory animals Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB84-241983. Portions of this document are not fully legible.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036