National Technical Reports Library - NTRL

National Technical Reports Library


Details
Actions:
Download PDFDownload XML
Download

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.


PB84241991

Publication Date 1984
Page Count 430
Abstract Data from a carcinogenicity study of foundry particulates, silica (14808607) and silica sand substitutes in hamsters are presented. Results indicated that silica sand and 10 silica sand substitutes were found not to be carcinogenic when administered by intratracheal instillation to male Syrian-Golden-hamsters. When given with benzo(a)pyrene (50328), the substances showed a definite cocarcinogenic effect in the hamster respiratory system. A tumor inventory and group and individual summaries of the histopathological findings of the study are provided. Organs and tissues examined for histopathological changes are listed. Tumors observed included squamous cell carcinomas, metastatic adenocarcinomas, polyps, cortical cell adenomas and reticular cell sarcomas. Mortality data is also provided.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Foundries
  • Carcinogens
  • Silicon dioxide
  • Particles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Sands
  • Mortality
  • Air pollution
  • Malignant neoplasms
  • Laboratory animals
  • Toxic substances
  • Occupational safety and health
  • CAS 14808-60-7
  • CAS 50-32-8
  • Benzopyrenes
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes See also Volume 2, PB84-241983. Portions of this document are not fully legible.
Document Type Technical Report
Title Note Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number 198426
Contract Number
  • PHS-NIOSH-210-79-0036
Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.
Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 3.
PB84241991

  • Environmental surveys
  • Industrial medicine
  • Foundries
  • Carcinogens
  • Silicon dioxide
  • Particles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Sands
  • Mortality
  • Air pollution
  • Malignant neoplasms
  • Laboratory animals
  • Toxic substances
  • Occupational safety and health
  • CAS 14808-60-7
  • CAS 50-32-8
  • Benzopyrenes
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-79-0036
Loading