Publication Date |
1984 |
Page Count |
430 |
Abstract |
Data from a carcinogenicity study of foundry particulates, silica (14808607) and silica sand substitutes in hamsters are presented. Results indicated that silica sand and 10 silica sand substitutes were found not to be carcinogenic when administered by intratracheal instillation to male Syrian-Golden-hamsters. When given with benzo(a)pyrene (50328), the substances showed a definite cocarcinogenic effect in the hamster respiratory system. A tumor inventory and group and individual summaries of the histopathological findings of the study are provided. Organs and tissues examined for histopathological changes are listed. Tumors observed included squamous cell carcinomas, metastatic adenocarcinomas, polyps, cortical cell adenomas and reticular cell sarcomas. Mortality data is also provided. |
Keywords |
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Source Agency |
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NTIS Subject Category |
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Corporate Authors |
Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. |
Supplemental Notes |
See also Volume 2, PB84-241983. Portions of this document are not fully legible. |
Document Type |
Technical Report |
Title Note |
Final rept. 21 Apr 80-26 Jan 83. |
NTIS Issue Number |
198426 |
Contract Number |
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