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Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.

PB84241983

Publication Date	1984
Page Count	172
Abstract	The carcinogenicity of silica (14808607) and silica sand substitutes in male Syrian-Golden-hamsters is reviewed. Hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. The only exception to this finding was seen with an aluminum (7429905) containing substitute. The tumors were classified as adenocarcinomas, squamous cell carcinomas, adenosquamous carcinomas, carcinomas, and sarcomas of various types. Benign tumors, mostly epithelial polyps, were found most frequently in the larynx and trachea. Analyses of the animal feed, Rodent Laboratory Chow, tabulations of clinical observations, and life table analyses of the animals that had tumors in the larynx, trachea, or lung are presented.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Laboratory animals Air pollution Malignant neoplasms Aluminum Mortality Sands Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 CAS 7429-90-5 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 1, PB84-241975, and Volume 3, PB84-241991.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.
PB84241983

Publication Date	1984
Page Count	172
Abstract	The carcinogenicity of silica (14808607) and silica sand substitutes in male Syrian-Golden-hamsters is reviewed. Hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. The only exception to this finding was seen with an aluminum (7429905) containing substitute. The tumors were classified as adenocarcinomas, squamous cell carcinomas, adenosquamous carcinomas, carcinomas, and sarcomas of various types. Benign tumors, mostly epithelial polyps, were found most frequently in the larynx and trachea. Analyses of the animal feed, Rodent Laboratory Chow, tabulations of clinical observations, and life table analyses of the animals that had tumors in the larynx, trachea, or lung are presented.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Laboratory animals Air pollution Malignant neoplasms Aluminum Mortality Sands Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 CAS 7429-90-5 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 1, PB84-241975, and Volume 3, PB84-241991.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036