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Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.


PB84241983

Publication Date 1984
Page Count 172
Abstract The carcinogenicity of silica (14808607) and silica sand substitutes in male Syrian-Golden-hamsters is reviewed. Hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. The only exception to this finding was seen with an aluminum (7429905) containing substitute. The tumors were classified as adenocarcinomas, squamous cell carcinomas, adenosquamous carcinomas, carcinomas, and sarcomas of various types. Benign tumors, mostly epithelial polyps, were found most frequently in the larynx and trachea. Analyses of the animal feed, Rodent Laboratory Chow, tabulations of clinical observations, and life table analyses of the animals that had tumors in the larynx, trachea, or lung are presented.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Foundries
  • Carcinogens
  • Silicon dioxide
  • Particles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Air pollution
  • Malignant neoplasms
  • Aluminum
  • Mortality
  • Sands
  • Toxic substances
  • Occupational safety and health
  • CAS 14808-60-7
  • CAS 50-32-8
  • CAS 7429-90-5
  • Benzopyrenes
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
  • 41I - Job Environment
Corporate Authors Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes See also Volume 1, PB84-241975, and Volume 3, PB84-241991.
Document Type Technical Report
Title Note Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number 198426
Contract Number
  • PHS-NIOSH-210-79-0036
Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.
Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 2.
PB84241983

  • Environmental surveys
  • Industrial medicine
  • Foundries
  • Carcinogens
  • Silicon dioxide
  • Particles
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Air pollution
  • Malignant neoplasms
  • Aluminum
  • Mortality
  • Sands
  • Toxic substances
  • Occupational safety and health
  • CAS 14808-60-7
  • CAS 50-32-8
  • CAS 7429-90-5
  • Benzopyrenes
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • 68A - Air Pollution & Control
  • 41I - Job Environment
  • PHS-NIOSH-210-79-0036
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