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Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 1.

PB84241975

Publication Date	1984
Page Count	198
Abstract	A carcinogenicity assay of silica (14808607) and silica sand substitutes was conducted. Male Syrian-Golden-hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. When given with BP, silica sand and the substitutes, except for an aluminum (7429905) silica formulation, caused a significantly higher incidence of respiratory tumors than BP alone. The authors conclude that silica and silica sand substitutes by themselves are not carcinogenic to the hamster respiratory tract. When instilled with BP, they show a definite cocarcinogenic response.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Mortality Air pollution Malignant neoplasms Laboratory animals Aluminum Sands Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 CAS 7429-90-5 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB84-241983.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 1.

Co-Carcinogenicity of Foundry Particulates Silica and Silica Sand Substitutes. Volume 1.
PB84241975

Publication Date	1984
Page Count	198
Abstract	A carcinogenicity assay of silica (14808607) and silica sand substitutes was conducted. Male Syrian-Golden-hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. When given with BP, silica sand and the substitutes, except for an aluminum (7429905) silica formulation, caused a significantly higher incidence of respiratory tumors than BP alone. The authors conclude that silica and silica sand substitutes by themselves are not carcinogenic to the hamster respiratory tract. When instilled with BP, they show a definite cocarcinogenic response.
Keywords	Environmental surveys Industrial medicine Foundries Carcinogens Silicon dioxide Particles Exposure Toxicity Inspection Hazardous materials Mortality Air pollution Malignant neoplasms Laboratory animals Aluminum Sands Toxic substances Occupational safety and health CAS 14808-60-7 CAS 50-32-8 CAS 7429-90-5 Benzopyrenes
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety 68A - Air Pollution & Control 41I - Job Environment
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also Volume 2, PB84-241983.
Document Type	Technical Report
Title Note	Final rept. 21 Apr 80-26 Jan 83.
NTIS Issue Number	198426
Contract Number	PHS-NIOSH-210-79-0036