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Endocrine Function of Workers Exposed to PBB and PBBO.

PB84238377

Publication Date	1982
Personal Author	Bialik, O.
Page Count	68
Abstract	Thyroid and reproductive dysfunction was investigated in workers exposed for at least 240 hours to decabromobiphenyl (13654096) (PBB) and decabromobiphenyloxide (1163195) over a 4 year period. The average period of employment was 3.9; mean age, 34.7. Medical questionnaires, physical examinations, and laboratory tests were conducted. Air samples of PBB in manufacturing area showed 0.18 to 0.23 milligrams per cubic meter for an 8 hour time weighted average. Of 18 workers exposed for 3 years or longer, thyroid nodules were seen in 3; another nodule was seen in a worker exposed to high chlorine (7782505) concentrations. Significant correlation was seen between length of employment and concentrations of follicle stimulating hormone (FSH) in workers exposed to PBB. An abnormal FSH value was found in only one worker. A testicular cyst was found in one exposed worker, and epididymal nodules in two others. No testicular or epididymal nodules were seen among comparisons. No detectable PBB was found in serum. The author concludes that thyroid hyperplasia may result from exposure to PBB, but no definite statement can be made concerning adverse effects on the prevalence of testicular and epididymal nodules because of their prevalence in the general population.
Keywords	Environmental surveys Industrial medicine Chlorine Endocrine diseases Exposure Toxicity Inspection Hazardous materials Bromine organic compounds Biphenyl/decabromo Toxic substances Occupational safety and health Biphenyl oxide/decabromo CAS 13654-09-6 CAS 1163-19-5 CAS 7782-50-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Pennsylvania Univ., Philadelphia. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Progress rept.
NTIS Issue Number	198426

Endocrine Function of Workers Exposed to PBB and PBBO.

Endocrine Function of Workers Exposed to PBB and PBBO.
PB84238377

Publication Date	1982
Personal Author	Bialik, O.
Page Count	68
Abstract	Thyroid and reproductive dysfunction was investigated in workers exposed for at least 240 hours to decabromobiphenyl (13654096) (PBB) and decabromobiphenyloxide (1163195) over a 4 year period. The average period of employment was 3.9; mean age, 34.7. Medical questionnaires, physical examinations, and laboratory tests were conducted. Air samples of PBB in manufacturing area showed 0.18 to 0.23 milligrams per cubic meter for an 8 hour time weighted average. Of 18 workers exposed for 3 years or longer, thyroid nodules were seen in 3; another nodule was seen in a worker exposed to high chlorine (7782505) concentrations. Significant correlation was seen between length of employment and concentrations of follicle stimulating hormone (FSH) in workers exposed to PBB. An abnormal FSH value was found in only one worker. A testicular cyst was found in one exposed worker, and epididymal nodules in two others. No testicular or epididymal nodules were seen among comparisons. No detectable PBB was found in serum. The author concludes that thyroid hyperplasia may result from exposure to PBB, but no definite statement can be made concerning adverse effects on the prevalence of testicular and epididymal nodules because of their prevalence in the general population.
Keywords	Environmental surveys Industrial medicine Chlorine Endocrine diseases Exposure Toxicity Inspection Hazardous materials Bromine organic compounds Biphenyl/decabromo Toxic substances Occupational safety and health Biphenyl oxide/decabromo CAS 13654-09-6 CAS 1163-19-5 CAS 7782-50-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Pennsylvania Univ., Philadelphia. School of Medicine.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Progress rept.
NTIS Issue Number	198426