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Mechanism of Action: Carcinogenic o-Methylarylamines.


PB84238310

Publication Date 1982
Personal Author Weisburger, J. H.; Fiala, E. S.; Hecht, S. S.
Page Count 43
Abstract The carcinogenicity of 3,2'-dimethyl-4-aminobiphenyl (13394860) (DMAB) and 3-methyl-2-naphthylamine (10546244) (MNA) was investigated in F344-rats, Charles-River-CDF-rats, Syrian-golden-hamsters, and guinea-pigs. Mutagenicity of aniline (62533) derivatives, MNA, DMAB, and ortho-toluidine (95534) was determined in Salmonella-typhimurium strains TA-100, TA-1535, and TA-1538, with or without rat liver S9 fraction. Rats and hamsters were given subcutaneous injections of MNA or DMAB for various periods then killed and necropsied. Rats were compared to hamsters in terms of susceptibility to DMAB carcinogenesis. Tritiated DMAB was given to hamsters and F344-rats. Bile was collected in cannulated animals and urine and feces were collected from nonoperated animals. DMAB produced mainly urinary bladder tumors in hamsters; MNA was less active, but caused local sarcoma at the injection site. Treatment with disulfiram (97778) decreased DMAB carcinogenicity in the small intestine in hamsters, while rats developed bladder tumors. No effect was seen on colon cancers. Prostate carcinomas occurred in male rats given DMAB but none were seen in hamsters. In Salmonella, compounds having a methyl group ortho to the amine were more mutagenic. Greater amounts of DMAB were excreted in the bile of rats than in hamsters. Hamsters excreted DMAB in urine, whereas rats did not.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Carcinogens
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Aniline
  • Nitrogen organic compounds
  • Rats
  • Biphenyl/amino-dimethyl
  • Toxic substances
  • Occupational safety and health
  • Naphthylamine/methyl
  • CAS 13394-86-0
  • CAS 10546-24-4
  • CAS 62-53-3
  • CAS 95-53-4
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors American Health Foundation, Valhalla, NY. Naylor Dana Inst. for Disease Prevention.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type Technical Report
NTIS Issue Number 198426
Mechanism of Action: Carcinogenic o-Methylarylamines.
Mechanism of Action: Carcinogenic o-Methylarylamines.
PB84238310

  • Environmental surveys
  • Industrial medicine
  • Carcinogens
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Aniline
  • Nitrogen organic compounds
  • Rats
  • Biphenyl/amino-dimethyl
  • Toxic substances
  • Occupational safety and health
  • Naphthylamine/methyl
  • CAS 13394-86-0
  • CAS 10546-24-4
  • CAS 62-53-3
  • CAS 95-53-4
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
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