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Carcinogenicity of Azo Dyes: Acid Black 52 and Yellow 3 in Hamsters and Rats. Volume 1.

PB84201136

Publication Date	1983
Personal Author	Plankenhorn, L. J.
Page Count	240
Abstract	The effects of Acid-black-52 (5610640) (AB52) and Yellow-3 (1342296) (Y3) were studied in rats and hamsters. AB52 and Y3 were administered intratracheally to Golden-Syrian-hamsters and Fischer-344-rats once a week for 15 weeks at concentrations of 0.56 to 3.16 milligrams per 0.2 milliliters of saline solution. AB52 and Y3 were administered orally for 27 months, the former at 2 percent and the latter at 0.8 percent in the diet. Animals were observed for clinical symptoms during the experiments. At the end of the experiments, all animals were killed, and complete necropsies and histopathological studies were concluded. AB52 was not found to be oncogenic in either species by either route of administration. Y3 given intratracheally was oncogenic in the adrenal cortex of male hamsters and in the pancreas of male rats. Y3 administered in the diet was oncogenic in the adrenal glands of both sexes of hamsters, in the liver and urinary tract of male rats, and in the endocrine system of female rats. The author concludes that AB52 is noncarcinogenic and Y3 is carcinogenic in rats and hamsters.
Keywords	Azo dyes Toxicology Dyes Bioassay Rats Hamsters Laboratory animals Dosage Ingestion(Biology) Diets Pathology Carcinogenesis CAS 56-10-640 CAS 13-42-296 Histopathology
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB84-201144.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198418
Contract Number	PHS-NIOSH-210-78-0032

Carcinogenicity of Azo Dyes: Acid Black 52 and Yellow 3 in Hamsters and Rats. Volume 1.

Carcinogenicity of Azo Dyes: Acid Black 52 and Yellow 3 in Hamsters and Rats. Volume 1.
PB84201136

Publication Date	1983
Personal Author	Plankenhorn, L. J.
Page Count	240
Abstract	The effects of Acid-black-52 (5610640) (AB52) and Yellow-3 (1342296) (Y3) were studied in rats and hamsters. AB52 and Y3 were administered intratracheally to Golden-Syrian-hamsters and Fischer-344-rats once a week for 15 weeks at concentrations of 0.56 to 3.16 milligrams per 0.2 milliliters of saline solution. AB52 and Y3 were administered orally for 27 months, the former at 2 percent and the latter at 0.8 percent in the diet. Animals were observed for clinical symptoms during the experiments. At the end of the experiments, all animals were killed, and complete necropsies and histopathological studies were concluded. AB52 was not found to be oncogenic in either species by either route of administration. Y3 given intratracheally was oncogenic in the adrenal cortex of male hamsters and in the pancreas of male rats. Y3 administered in the diet was oncogenic in the adrenal glands of both sexes of hamsters, in the liver and urinary tract of male rats, and in the endocrine system of female rats. The author concludes that AB52 is noncarcinogenic and Y3 is carcinogenic in rats and hamsters.
Keywords	Azo dyes Toxicology Dyes Bioassay Rats Hamsters Laboratory animals Dosage Ingestion(Biology) Diets Pathology Carcinogenesis CAS 56-10-640 CAS 13-42-296 Histopathology
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Borriston Labs., Inc., Temple Hills, MD.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Supplemental Notes	See also PB84-201144.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198418
Contract Number	PHS-NIOSH-210-78-0032