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Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate.

PB83258038

Publication Date	1982
Personal Author	Hackett, P. L.; Brown, M. G.; Buschbom, R. L.; Clark, M. L.; Miller, R. A.
Page Count	150
Abstract	Maternal toxicity, reproductive performance, and developmental toxicology were evaluated in rats and rabbits following 7 hr/day inhalation exposures to 150 ppm ethylene oxide, 500 ppm propylene oxide or 1500 ppmn-butyl acetate. Rabbits were artificially inseminated and placed on one of the following exposure regimen for each chemical: (1) filtered air (control), (2) chemical exposure from 7 through 19 days of gestation (dg), and (3) chemical exposure from 1 through 19 dg. Rat-exposure regimens for each chemical were: (1) filtered air (control, (2) chemical exposure from 7 through 16 dg, (3) chemical exposure from 1 through 16 dg, and (4) chemical exposure for 5 days/wk for 3 wk prior to mating and daily from 1 through 16 dg. Unexposed males were used in mating and artificial insemination procedures.
Keywords	Toxicology Ethylene oxide Propylene oxide Rats Rabbits Laboratory animals Reproduction(Biology) Respiration Acetic acid/(butyl-ester) Teratogenesis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198326
Contract Number	PHS-NIOSH-210-80-0013

Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate.

Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate.
PB83258038

Publication Date	1982
Personal Author	Hackett, P. L.; Brown, M. G.; Buschbom, R. L.; Clark, M. L.; Miller, R. A.
Page Count	150
Abstract	Maternal toxicity, reproductive performance, and developmental toxicology were evaluated in rats and rabbits following 7 hr/day inhalation exposures to 150 ppm ethylene oxide, 500 ppm propylene oxide or 1500 ppmn-butyl acetate. Rabbits were artificially inseminated and placed on one of the following exposure regimen for each chemical: (1) filtered air (control), (2) chemical exposure from 7 through 19 days of gestation (dg), and (3) chemical exposure from 1 through 19 dg. Rat-exposure regimens for each chemical were: (1) filtered air (control, (2) chemical exposure from 7 through 16 dg, (3) chemical exposure from 1 through 16 dg, and (4) chemical exposure for 5 days/wk for 3 wk prior to mating and daily from 1 through 16 dg. Unexposed males were used in mating and artificial insemination procedures.
Keywords	Toxicology Ethylene oxide Propylene oxide Rats Rabbits Laboratory animals Reproduction(Biology) Respiration Acetic acid/(butyl-ester) Teratogenesis
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57E - Clinical Medicine 68G - Environmental Health & Safety
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198326
Contract Number	PHS-NIOSH-210-80-0013