Publication Date |
1974 |
Personal Author |
Stewart, R. D.; Hake, C. L.; Forster, H. V.; Lebrun, A. J.; Peterson, J. E. |
Page Count |
92 |
Abstract |
Twenty healthy adults of both sexes were exposed to methylene chloride vapor concentrations of 0, 50, 100, 250 and 500 ppm for periods of 1, 3 and 7-1/2 hours in a controlled-environment chamber. These studies were designed to simulate the type of exposures encountered in the industrial setting and consisted of both steady, non-fluctuating vapor concentrations as well as widely fluctuating vapor concentrations. Exposure resulted in a prompt elevation of carboxyhemoglobin (COHb) which had a biologic half-life twice that of COHb formed as a result of exposure to exogenous carbon monoxide. Post-exposure breath analysis for methylene chloride and its metabolite, carbon monoxide, proved to be a practical screening method with which to determine the body burden of these two compounds and so provides a biologic threshold limit measurement for workmen. |
Keywords |
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Source Agency |
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NTIS Subject Category |
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Corporate Authors |
Medical Coll. of Wisconsin, Inc., Milwaukee. Allen-Bradley Medical Science Lab.; National Inst. for Occupational Safety and Health, Cincinnati, OH. |
Document Type |
Technical Report |
NTIS Issue Number |
198324 |
Contract Number |
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