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Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.


PB83244301

Publication Date 1982
Personal Author Renne, R. A.; Eldridge, S. R.; Stevens, D. L.
Page Count 86
Abstract The purpose of this study was to determine the type and extent of pulmonary fibrosis experimentally induced in hamsters by intratracheal instillations of quartz, fibrous glass, hydrated alumina, or a 1:1 mixture of quartz and ferric oxide. The objective was to determine a dose of each material which would induce a pronounced pulmonary fibrosis without compromising the life expectance of the animal. Dose-related decreases in survival were evident for the groups instilled with the two highest doses of quartz or quartz and ferric oxide. A dose-related increase in lung weight was most apparent in those groups instilled with quartz or quartz and ferric oxide. A correlation between the incidence and severity of alveolar septal fibrosis and the dose of instilled material was evident in most groups, being strongest in those groups exposed to quartz or quartz and ferric oxide. These materials induced the most intense pulmonary fibrotic response.
Keywords
  • Respiratory diseases
  • Toxicology
  • Air pollution
  • Etiology
  • Hamsters
  • Glass fibers
  • Quartz
  • Alumina
  • Ferric oxide
  • Pulmonary fibrosis
  • Cancer
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 68A - Air Pollution & Control
Corporate Authors Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type Technical Report
Title Note Final rept.
NTIS Issue Number 198324
Contract Number
  • PHS-NIOSH-210-79-0038
Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.
Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.
PB83244301

  • Respiratory diseases
  • Toxicology
  • Air pollution
  • Etiology
  • Hamsters
  • Glass fibers
  • Quartz
  • Alumina
  • Ferric oxide
  • Pulmonary fibrosis
  • Cancer
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 68A - Air Pollution & Control
  • PHS-NIOSH-210-79-0038
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