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Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.

PB83244301

Publication Date	1982
Personal Author	Renne, R. A.; Eldridge, S. R.; Stevens, D. L.
Page Count	86
Abstract	The purpose of this study was to determine the type and extent of pulmonary fibrosis experimentally induced in hamsters by intratracheal instillations of quartz, fibrous glass, hydrated alumina, or a 1:1 mixture of quartz and ferric oxide. The objective was to determine a dose of each material which would induce a pronounced pulmonary fibrosis without compromising the life expectance of the animal. Dose-related decreases in survival were evident for the groups instilled with the two highest doses of quartz or quartz and ferric oxide. A dose-related increase in lung weight was most apparent in those groups instilled with quartz or quartz and ferric oxide. A correlation between the incidence and severity of alveolar septal fibrosis and the dose of instilled material was evident in most groups, being strongest in those groups exposed to quartz or quartz and ferric oxide. These materials induced the most intense pulmonary fibrotic response.
Keywords	Respiratory diseases Toxicology Air pollution Etiology Hamsters Glass fibers Quartz Alumina Ferric oxide Pulmonary fibrosis Cancer
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198324
Contract Number	PHS-NIOSH-210-79-0038

Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.

Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.
PB83244301

Publication Date	1982
Personal Author	Renne, R. A.; Eldridge, S. R.; Stevens, D. L.
Page Count	86
Abstract	The purpose of this study was to determine the type and extent of pulmonary fibrosis experimentally induced in hamsters by intratracheal instillations of quartz, fibrous glass, hydrated alumina, or a 1:1 mixture of quartz and ferric oxide. The objective was to determine a dose of each material which would induce a pronounced pulmonary fibrosis without compromising the life expectance of the animal. Dose-related decreases in survival were evident for the groups instilled with the two highest doses of quartz or quartz and ferric oxide. A dose-related increase in lung weight was most apparent in those groups instilled with quartz or quartz and ferric oxide. A correlation between the incidence and severity of alveolar septal fibrosis and the dose of instilled material was evident in most groups, being strongest in those groups exposed to quartz or quartz and ferric oxide. These materials induced the most intense pulmonary fibrotic response.
Keywords	Respiratory diseases Toxicology Air pollution Etiology Hamsters Glass fibers Quartz Alumina Ferric oxide Pulmonary fibrosis Cancer
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 68A - Air Pollution & Control
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198324
Contract Number	PHS-NIOSH-210-79-0038