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Screening of Priority Chemicals for Potential Reproductive Hazard.

PB83213017

Publication Date	1983
Personal Author	Booth, G. M.; Bradshaw, W. S.; Carter, M. W.
Page Count	104
Abstract	The objective of this work was to determine the effect of nine chemicals on selected reproductive parameters in pregnant white mice. The nine chemicals were diethylene glycol diethyl ether, ethylenethiourea, sodium selenite, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, p-nitrophenol, dimethyl phthalate, and naphthalene. The study was divided into two parts: (1) Determination of a Maximum Tolerated Dose (MTD) based on adult mortality and weight loss, and (2) A Reproductive Study in which the MTD dose was administered to pregnant SPF CD-1 mice. Both the MTD and reproductive portions of the investigation were completed in blocks of three chemicals each or a total of three blocks for the nine compounds.
Keywords	Environmental surveys Industrial medicine Chemical compounds Exposure Toxicity Inspection Hazardous materials Naphthalene Oxygen organic compounds Toxic substances Occupational safety and health Ether/diethyl Sodium selenite Phthalic acid/(dimethyl-ester) Phenol/nitro Ether/bis(ethoxyethyl) Maximum permissible exposure Imidazolidine thione Ethane/dimethoxy Ether/bis(methoxyethyl) Tetraoxadodecane
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	MESA Corp., Orem, UT.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198319
Contract Number	PHS-NIOSH-210-81-6012

Screening of Priority Chemicals for Potential Reproductive Hazard.

Screening of Priority Chemicals for Potential Reproductive Hazard.
PB83213017

Publication Date	1983
Personal Author	Booth, G. M.; Bradshaw, W. S.; Carter, M. W.
Page Count	104
Abstract	The objective of this work was to determine the effect of nine chemicals on selected reproductive parameters in pregnant white mice. The nine chemicals were diethylene glycol diethyl ether, ethylenethiourea, sodium selenite, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, p-nitrophenol, dimethyl phthalate, and naphthalene. The study was divided into two parts: (1) Determination of a Maximum Tolerated Dose (MTD) based on adult mortality and weight loss, and (2) A Reproductive Study in which the MTD dose was administered to pregnant SPF CD-1 mice. Both the MTD and reproductive portions of the investigation were completed in blocks of three chemicals each or a total of three blocks for the nine compounds.
Keywords	Environmental surveys Industrial medicine Chemical compounds Exposure Toxicity Inspection Hazardous materials Naphthalene Oxygen organic compounds Toxic substances Occupational safety and health Ether/diethyl Sodium selenite Phthalic acid/(dimethyl-ester) Phenol/nitro Ether/bis(ethoxyethyl) Maximum permissible exposure Imidazolidine thione Ethane/dimethoxy Ether/bis(methoxyethyl) Tetraoxadodecane
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	MESA Corp., Orem, UT.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	198319
Contract Number	PHS-NIOSH-210-81-6012