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Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol.

PB83208074

Publication Date	1981
Personal Author	Andres, F. D.; Buschbom, R. L.; Cannon, W. C.; Miller, R. A.; Hardin, B. D.
Page Count	110
Abstract	These experiments were performed to evaluate developmental toxicity in rats and rabbits associated with inhalation exposure to ethylbenzene (EB) or 2-ethoxyethanol (EE). Rats were exposed for 7 hours per day, 5 days per week for 3 weeks. They were then mated and exposed daily through 19 days of gestation (d.g.). Rabbits were artificially inseminated and exposed for 7 hours daily through 18 d.g. (EE) or 24 d.g. (EB). The rats were killed and examined at 21 d.g. and the rabbits at 30 d.g. Pregnant animals were observed for evidence of toxicity including altered food consumption, body weight gains and tissue weights and for histopathologic changes. Litters are examined for the presence of external, visceral and skeletal defects as well as the incidence of growth retardation and intrauterine mortality.
Keywords	Toxicology Inhalation Rats Rabbits Laboratory animals Histology Pathology Growth Survival Reproduction(Biology) Fertility Teratogenesis Ethylbenzene Ethoxyethanol
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198318
Contract Number	PHS-NIOSH-210-79-0037

Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol.

Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol.
PB83208074

Publication Date	1981
Personal Author	Andres, F. D.; Buschbom, R. L.; Cannon, W. C.; Miller, R. A.; Hardin, B. D.
Page Count	110
Abstract	These experiments were performed to evaluate developmental toxicity in rats and rabbits associated with inhalation exposure to ethylbenzene (EB) or 2-ethoxyethanol (EE). Rats were exposed for 7 hours per day, 5 days per week for 3 weeks. They were then mated and exposed daily through 19 days of gestation (d.g.). Rabbits were artificially inseminated and exposed for 7 hours daily through 18 d.g. (EE) or 24 d.g. (EB). The rats were killed and examined at 21 d.g. and the rabbits at 30 d.g. Pregnant animals were observed for evidence of toxicity including altered food consumption, body weight gains and tissue weights and for histopathologic changes. Litters are examined for the presence of external, visceral and skeletal defects as well as the incidence of growth retardation and intrauterine mortality.
Keywords	Toxicology Inhalation Rats Rabbits Laboratory animals Histology Pathology Growth Survival Reproduction(Biology) Fertility Teratogenesis Ethylbenzene Ethoxyethanol
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Document Type	Technical Report
NTIS Issue Number	198318
Contract Number	PHS-NIOSH-210-79-0037