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Details

PB83152397

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	182
Abstract	The Tier II mutagenic screening of hexachloro-1,3-butadiene (87683) (HCBD) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 0.15 to 1000 micrograms per milliliter HCBD. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 10 or 50 parts per million (ppm) HCBD for 7 hours per day for 1 or 5 days. The author concludes that HCBD was not mutagenic under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Chlorine organic compounds Mutagens Bioassay Deoxyribonucleric acid Butadiene/hexachloro Toxic substances Occupational safety and health Mutagenesis CAS 87-68-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Hexachloro-1,3-Butadiene.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Hexachloro-1,3-Butadiene.
PB83152397

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	182
Abstract	The Tier II mutagenic screening of hexachloro-1,3-butadiene (87683) (HCBD) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 0.15 to 1000 micrograms per milliliter HCBD. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 10 or 50 parts per million (ppm) HCBD for 7 hours per day for 1 or 5 days. The author concludes that HCBD was not mutagenic under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Chlorine organic compounds Mutagens Bioassay Deoxyribonucleric acid Butadiene/hexachloro Toxic substances Occupational safety and health Mutagenesis CAS 87-68-3
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026