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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Butylene Oxide.

PB83151704

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	198
Abstract	The Tier II mutagenic screening of butylene-oxide (109999) (BO) was conducted. The unschedule DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 11 to 7300 micrograms per milliliter BO. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 250 or 1000 parts per million (ppm) BO for 7 hours per day for 1 or 5 days. Dominant lethal test in male rats and sperm abnormality tests in male mice were performed after in vivo exposure to 250 or 1000 ppm BO for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 7 hour exposure to 1000ppm. BO produced no increases in UDS, sperm abnormality frequency, or sex linked recessive lethal mutation frequency. No effects due to BO exposure were observed in the dominant lethal assay. The author concludes that BO showed no mutagenic activity under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Mutagens Bioassay Deoxyribonucleic acid Butylene oxide Toxic substances Occupational safety and health Mutagenesis CAS 109-99-9
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Butylene Oxide.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Butylene Oxide.
PB83151704

Publication Date	1981
Personal Author	McGregor, D. B.
Page Count	198
Abstract	The Tier II mutagenic screening of butylene-oxide (109999) (BO) was conducted. The unschedule DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 11 to 7300 micrograms per milliliter BO. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 250 or 1000 parts per million (ppm) BO for 7 hours per day for 1 or 5 days. Dominant lethal test in male rats and sperm abnormality tests in male mice were performed after in vivo exposure to 250 or 1000 ppm BO for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 7 hour exposure to 1000ppm. BO produced no increases in UDS, sperm abnormality frequency, or sex linked recessive lethal mutation frequency. No effects due to BO exposure were observed in the dominant lethal assay. The author concludes that BO showed no mutagenic activity under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Mutagens Bioassay Deoxyribonucleic acid Butylene oxide Toxic substances Occupational safety and health Mutagenesis CAS 109-99-9
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026