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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.

PB83149732

Publication Date	1980
Personal Author	McGregor, D. B.
Page Count	186
Abstract	The Tier II mutagenic screening of N,N-dimethylacetamide (127195) (DMA) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 70 to 9366 micrograms per milliliter DMA. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 20 or 700 parts per million (ppm) DMA for 7 hours per day for 1 or 5 days. Dominant lethal tests in male rats and sperm abnormality tests in male mice were performed after in vivo exposure to 20 or 700ppm DMA for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 95 minute exposure to 200ppm. DMA produced no increases in UDS, sex linked recessive lethal frequency, abnormal sperm frequency, or rat bone marrow cell DNA aberrations. No effects due to DMA exposure were observed in the dominant lethal assay. The author concludes that DMA showed no mutagenic activity under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Mutagens Bioassay Deoxyribonucleic acid Acetamide/N-N-dimethyl Toxic substances Occupational safety and health Mutagenesis CAS 127-19-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.
PB83149732

Publication Date	1980
Personal Author	McGregor, D. B.
Page Count	186
Abstract	The Tier II mutagenic screening of N,N-dimethylacetamide (127195) (DMA) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 70 to 9366 micrograms per milliliter DMA. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 20 or 700 parts per million (ppm) DMA for 7 hours per day for 1 or 5 days. Dominant lethal tests in male rats and sperm abnormality tests in male mice were performed after in vivo exposure to 20 or 700ppm DMA for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 95 minute exposure to 200ppm. DMA produced no increases in UDS, sex linked recessive lethal frequency, abnormal sperm frequency, or rat bone marrow cell DNA aberrations. No effects due to DMA exposure were observed in the dominant lethal assay. The author concludes that DMA showed no mutagenic activity under these test conditions.
Keywords	Environmental surveys Industrial medicine Screening Exposure Toxicity Inspection Hazardous materials Mutagens Bioassay Deoxyribonucleic acid Acetamide/N-N-dimethyl Toxic substances Occupational safety and health Mutagenesis CAS 127-19-5
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type	Technical Report
NTIS Issue Number	198310
Contract Number	PHS-NIOSH-210-78-0026