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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.


PB83149732

Publication Date 1980
Personal Author McGregor, D. B.
Page Count 186
Abstract The Tier II mutagenic screening of N,N-dimethylacetamide (127195) (DMA) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 70 to 9366 micrograms per milliliter DMA. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 20 or 700 parts per million (ppm) DMA for 7 hours per day for 1 or 5 days. Dominant lethal tests in male rats and sperm abnormality tests in male mice were performed after in vivo exposure to 20 or 700ppm DMA for 7 hours per day for 5 days. The sex linked recessive lethal test was performed using Drosophila-melanogaster after a 95 minute exposure to 200ppm. DMA produced no increases in UDS, sex linked recessive lethal frequency, abnormal sperm frequency, or rat bone marrow cell DNA aberrations. No effects due to DMA exposure were observed in the dominant lethal assay. The author concludes that DMA showed no mutagenic activity under these test conditions.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Screening
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Mutagens
  • Bioassay
  • Deoxyribonucleic acid
  • Acetamide/N-N-dimethyl
  • Toxic substances
  • Occupational safety and health
  • Mutagenesis
  • CAS 127-19-5
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH. Div.
Document Type Technical Report
NTIS Issue Number 198310
Contract Number
  • PHS-NIOSH-210-78-0026
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, N,N-Dimethylacetamide.
PB83149732

  • Environmental surveys
  • Industrial medicine
  • Screening
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Mutagens
  • Bioassay
  • Deoxyribonucleic acid
  • Acetamide/N-N-dimethyl
  • Toxic substances
  • Occupational safety and health
  • Mutagenesis
  • CAS 127-19-5
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
  • PHS-NIOSH-210-78-0026
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