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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, BIS(2-Methoxyethyl) Ether.


PB83138198

Publication Date 1981
Personal Author McGregor, D. B.
Page Count 196
Abstract Bis(2-methoxyethyl)-ether (111966) (BME) was subjected to a tier II mutagenic screening program. Screening assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 19,000 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposures to atmospheres containing 250 parts per million (ppm) or 1000ppm BME for 7 hours per day for 5 days; sperm abnormality test in male mice using the same exposures conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; sex-linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 250ppm for 2.75 hours. There was no increase in UDS in cells treated with BME; clinical signs of toxicity occurred in animals exposed to 1000ppm BME atmospheres; male rat fertility was drastically reduced following exposure to 1000ppm BME in the dominant lethal test; a significant reduction in total aberrant cell frequency occurred; and abnormal sperm frequency was increased. The author concludes that BME may be a weak mutagen, but the adverse effect upon reproductive capacity is probably the more important aspect of its toxicology.
Keywords
  • Bioassay
  • Toxicology
  • Humans
  • Exposure
  • Fertility
  • Genetics
  • Rats
  • Laboratory animals
  • Mutagens
  • Oxygen organic compounds
  • Ether/bis(methoxyethyl)
  • Mutagenesis
  • CAS 111-96-6
  • Medical research
  • Health screening
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57Y - Toxicology
  • 57E - Clinical Medicine
Corporate Authors Inveresk Research International Ltd., Musselburgh (Scotland).; National Inst. for Occupational Safety and Health, Cincinnati, OH.
Supplemental Notes See also PB83-113407.
Document Type Technical Report
NTIS Issue Number 198305
Contract Number
  • PHS-NIOSH-210-78-0026
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, BIS(2-Methoxyethyl) Ether.
Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, BIS(2-Methoxyethyl) Ether.
PB83138198

  • Bioassay
  • Toxicology
  • Humans
  • Exposure
  • Fertility
  • Genetics
  • Rats
  • Laboratory animals
  • Mutagens
  • Oxygen organic compounds
  • Ether/bis(methoxyethyl)
  • Mutagenesis
  • CAS 111-96-6
  • Medical research
  • Health screening
  • National Institute for Occupational Safety and Health
  • 57Y - Toxicology
  • 57E - Clinical Medicine
  • PHS-NIOSH-210-78-0026
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