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DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.


PB83137992

Publication Date 1980
Personal Author Smith, J. P.; Baron, P. A.; Doemeny, L. J.; Sterling, D. C.; Kennedy, E.
Page Count 22
Abstract Substitutes for the test agent diethyl(hexyl)phthalate (117817) (DOP) used in respirator quantitative fit testing were investigated. Recent medical evidence has implicated DOP in the causation of liver cancer in test animals. Several model fluids with physical properties similar to those of DOP were examined. They were: diethyl(hexyl)sebacate (122623), linoleic-acid (60333), oleic-acid (112801), dimethicone (9006659), and corn-oil. The fit test apparatus generated aerosols from these fluids and chemical properties were observed. The fit test apparatus was capable of producing the required quantities of aerosol from all the fluids tested. Mass median diameters and geometric standard deviations of the aerosols were all comparable. The required protection factor could be measured with the aerosols produced from any of the oils tested. The authors note that oils with physical properties similar to those of DOP are potential candidate materials for use in quantitative fit testing.
Keywords
  • Environmental surveys
  • Industrial medicine
  • Aerosol generators
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Linoleic acids
  • Oleic acid
  • Corn
  • Vegetable oils
  • Oxygen organic compounds
  • Phthalic acid/(dioctyl-ester)
  • Toxic substances
  • Occupational safety and health
  • Cancer
  • CAS 117-81-7
  • CAS 122-62-3
  • CAS 60-33-3
  • Dimethicone
  • CAS 112-80-1
  • CAS 9006-65-9
  • Sebacic acid/(dioctyl-ester)
Source Agency
  • National Institute for Occupational Safety and Health
NTIS Subject Category
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
Corporate Authors National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Physical Sciences and Engineering.
Document Type Technical Report
Title Note Technical rept.
NTIS Issue Number 198307
DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.
DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.
PB83137992

  • Environmental surveys
  • Industrial medicine
  • Aerosol generators
  • Exposure
  • Toxicity
  • Inspection
  • Hazardous materials
  • Laboratory animals
  • Linoleic acids
  • Oleic acid
  • Corn
  • Vegetable oils
  • Oxygen organic compounds
  • Phthalic acid/(dioctyl-ester)
  • Toxic substances
  • Occupational safety and health
  • Cancer
  • CAS 117-81-7
  • CAS 122-62-3
  • CAS 60-33-3
  • Dimethicone
  • CAS 112-80-1
  • CAS 9006-65-9
  • Sebacic acid/(dioctyl-ester)
  • National Institute for Occupational Safety and Health
  • 57U - Public Health & Industrial Medicine
  • 57Y - Toxicology
  • 94D - Job Environment
  • 68G - Environmental Health & Safety
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