National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.

PB83137992

Publication Date	1980
Personal Author	Smith, J. P.; Baron, P. A.; Doemeny, L. J.; Sterling, D. C.; Kennedy, E.
Page Count	22
Abstract	Substitutes for the test agent diethyl(hexyl)phthalate (117817) (DOP) used in respirator quantitative fit testing were investigated. Recent medical evidence has implicated DOP in the causation of liver cancer in test animals. Several model fluids with physical properties similar to those of DOP were examined. They were: diethyl(hexyl)sebacate (122623), linoleic-acid (60333), oleic-acid (112801), dimethicone (9006659), and corn-oil. The fit test apparatus generated aerosols from these fluids and chemical properties were observed. The fit test apparatus was capable of producing the required quantities of aerosol from all the fluids tested. Mass median diameters and geometric standard deviations of the aerosols were all comparable. The required protection factor could be measured with the aerosols produced from any of the oils tested. The authors note that oils with physical properties similar to those of DOP are potential candidate materials for use in quantitative fit testing.
Keywords	Environmental surveys Industrial medicine Aerosol generators Exposure Toxicity Inspection Hazardous materials Laboratory animals Linoleic acids Oleic acid Corn Vegetable oils Oxygen organic compounds Phthalic acid/(dioctyl-ester) Toxic substances Occupational safety and health Cancer CAS 117-81-7 CAS 122-62-3 CAS 60-33-3 Dimethicone CAS 112-80-1 CAS 9006-65-9 Sebacic acid/(dioctyl-ester)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Physical Sciences and Engineering.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198307

DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.

DOP Substitutes for Quantitative Fit Testing: Aerosol Generation and Detection.
PB83137992

Publication Date	1980
Personal Author	Smith, J. P.; Baron, P. A.; Doemeny, L. J.; Sterling, D. C.; Kennedy, E.
Page Count	22
Abstract	Substitutes for the test agent diethyl(hexyl)phthalate (117817) (DOP) used in respirator quantitative fit testing were investigated. Recent medical evidence has implicated DOP in the causation of liver cancer in test animals. Several model fluids with physical properties similar to those of DOP were examined. They were: diethyl(hexyl)sebacate (122623), linoleic-acid (60333), oleic-acid (112801), dimethicone (9006659), and corn-oil. The fit test apparatus generated aerosols from these fluids and chemical properties were observed. The fit test apparatus was capable of producing the required quantities of aerosol from all the fluids tested. Mass median diameters and geometric standard deviations of the aerosols were all comparable. The required protection factor could be measured with the aerosols produced from any of the oils tested. The authors note that oils with physical properties similar to those of DOP are potential candidate materials for use in quantitative fit testing.
Keywords	Environmental surveys Industrial medicine Aerosol generators Exposure Toxicity Inspection Hazardous materials Laboratory animals Linoleic acids Oleic acid Corn Vegetable oils Oxygen organic compounds Phthalic acid/(dioctyl-ester) Toxic substances Occupational safety and health Cancer CAS 117-81-7 CAS 122-62-3 CAS 60-33-3 Dimethicone CAS 112-80-1 CAS 9006-65-9 Sebacic acid/(dioctyl-ester)
Source Agency	National Institute for Occupational Safety and Health
NTIS Subject Category	57U - Public Health & Industrial Medicine 57Y - Toxicology 94D - Job Environment 68G - Environmental Health & Safety
Corporate Authors	National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Physical Sciences and Engineering.
Document Type	Technical Report
Title Note	Technical rept.
NTIS Issue Number	198307